ArticleInternational journal of clinical and experimental medicine2015
Tumor-infiltrating memory T-lymphocytes for prognostic prediction in cancer patients: a meta-analysis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Associations Between Body Composition and Intratumoural Immune Cells in Patients With Uterine Cervical Cancer.Journal of cachexia, sarcopenia and muscle · 2026Article
- Systemic and local immunosuppression in glioblastoma and its prognostic significance.Frontiers in immunology · 2024Review
- Modification of Breast Cancer Milieu with Chemotherapy plus Dendritic Cell Vaccine: An Approach to Select Best Therapeutic Strategies.Biomedicines · 2023Article
- The predictive value of the preoperative systemic immune-inflammation index in the occurrence of postoperative pneumonia in non-small cell lung cancer: A retrospective study based on 1486 cases.Thoracic cancer · 2023Article
- Article
- Increased Immune-Regulatory Receptor Expression on Effector T Cells as Early Indicators of Relapse Following Autologous Stem Cell Transplantation for Multiple Myeloma.Frontiers in immunology · 2021Article
- T Cell Receptor Repertoires AcquiredFrontiers in immunology · 2021Article
- Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40.Cancer gene therapy · 2020Article
- Association of macrophage and lymphocyte infiltration with outcome in canine osteosarcoma.Veterinary and comparative oncology · 2019Article
- HDAC6 selective inhibition of melanoma patient T-cells augments anti-tumor characteristics.Journal for immunotherapy of cancer · 2019Article
- Striking a Balance-Cellular and Molecular Drivers of Memory T Cell Development and Responses to Chronic Stimulation.Frontiers in immunology · 2019Review
- Systemic immune-inflammation index (SII) is useful to predict survival outcomes in patients with surgically resected esophageal squamous cell carcinoma.Journal of Cancer · 2019Article
- PD-1+ TIM-3+ T cells in malignant ascites predict prognosis of gastrointestinal cancer.Cancer science · 2018Article
- PD1 is expressed on exhausted T cells as well as virus specific memory CD8+ T cells in the bone marrow of myeloma patients.Oncotarget · 2018Article
- Prognostic value of CD8CD45RO tumor infiltrating lymphocytes in patients with extrahepatic cholangiocarcinoma.Oncotarget · 2018Article
- Identification of shared TCR sequences from T cells in human breast cancer using emulsion RT-PCR.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- CD45RO(+) Memory T Lymphocytes--a Candidate Marker for TNM-Immunoscore in Squamous Non-Small Cell Lung Cancer.Neoplasia (New York, N.Y.) · 2015Article
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Authors and funding
3 authors.
Funding
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Abstract
purposePathological evidence has continually supported the prognostic value of tumour-infiltrating T lymphocytes for several solid tumours across diverse patient cohorts. To investigate the clinical relevance of tumour-infiltrating memory T lymphocytes, we investigated relevant publications to identify the significance of memory tumour-infiltrating T lymphocytes (TILs) in predicting survival in cancer patients and analysed the influence of variations in the tumour stage and the infiltrated location thereon.
methodsRelevant publications that assessed the clinical relevance of memory TILs to the patient's overall survival (OS) were investigated. Disease-free survival (DFS) was also evaluated where possible. Hazard ratios (HR) and 95% confidence intervals (CI) were assessed using a random-effects model. Heterogeneity was investigated with stratified analysis and I(2) statistics.
resultsIn total, 16 relevant publications, including 4248 cancer patients, were analysed. In the pooled analysis, intra-tumour accumulation of memory TILs correlated positively with favourable clinical outcomes for both OS (pooled HR, 2.06; 95% CI, 1.76-2.40) and DFS (pooled HR, 2.31; 95% CI, 1.67-3.19). Various effects of the tumour stage and the anatomical region where the cells infiltrated were identified in survival prediction, using memory TILs.
conclusionsOverall, infiltration of memory TILs can serve as a biomarker for survival prediction in cancer. Additional heterogeneous effects of the associated factors should be considered when categorizing high-risk patients.
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