ArticleInternational journal of clinical and experimental medicine2015
MiR-16 family as potential diagnostic biomarkers for cancer: a systematic review and meta-analysis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of the Expression Level of miR-16 with Prognosis of Solid Cancer Patients: A Meta-Analysis and Bioinformatic Analysis.Disease markers · 2020Pooled it
- The dual actions of miRNA16a in restricting Bovine Coronavirus replication through downregulation of Furin and enhancing the host immune response.Scientific reports · 2024Article
- Potential of miRNAs in Plasma Extracellular Vesicle for the Stratification of Prostate Cancer in a South African Population.Cancers · 2023Article
- TFAP2A potentiates lung adenocarcinoma metastasis by a novel miR-16 family/TFAP2A/PSG9/TGF-β signaling pathway.Cell death & disease · 2021Article
- Combination of circulating miR-145-5p/miR-191-5p as biomarker for breast cancer detection.PeerJ · 2020Article
- Validation of miR-1228-3p as Housekeeping for MicroRNA Analysis in Liquid Biopsies from Colorectal Cancer Patients.Biomolecules · 2019Article
- Electrochemical sensors and biosensors based on the use of polyaniline and its nanocomposites: a review on recent advances.Mikrochimica acta · 2019Review
- MiR-15a/16-1 deficiency induces IL-10-producing CD19Journal of cellular and molecular medicine · 2019Article
- RGS4 Regulates Proliferation And Apoptosis Of NSCLC Cells Via microRNA-16 And Brain-Derived Neurotrophic Factor.OncoTargets and therapy · 2019Article
- Tumor characterization by ultrasound-release of multiple protein and microRNA biomarkers, preclinical and clinical evidence.PloS one · 2018Article
- Decreased microRNA-181a and -16 expression levels in the labial salivary glands of Sjögren syndrome patients.Experimental and therapeutic medicine · 2018Article
- Clinical impact of circulating microRNAs as blood-based marker in childhood acute lymphoblastic leukemia.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Diagnostic and prognostic potential of serum miR-7, miR-16, miR-25, miR-93, miR-182, miR-376a and miR-429 in ovarian cancer patients.British journal of cancer · 2015Article
- Diagnostic value of bone-specific alkaline phosphatase in lung carcinoma patients with bone metastases: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- The functional role of microRNA in acute lymphoblastic leukemia: relevance for diagnosis, differential diagnosis, prognosis, and therapy.OncoTargets and therapy · 2015Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCancer is a main public health problem all over the world with its high morbidity and mortality. MicroRNA-16 (miRNA-16, miR-16) family members have been considered as potential biomarkers in cancer diagnosis in several previous studies, but their results were inconsistent.
objectiveThe present meta-analysis was conducted to assess the diagnostic efficacy of miR-16 family for cancer systematically.
methodsMultiple search strategies and random-effects model were used. Pooled sensitivity, specificity and other parameters were calculated. Totally, 1,259 cancer patients and 855 controls from 16 articles were enrolled in this meta-analysis.
resultsThe pooled results for sensitivity, specificity, positive likelihood ratios (PLR), negative likelihood ratios (NLR), diagnostic odds ratio (DOR) and the area under the curve (AUC) were 0.80 (95% CI: 0.73-0.85), 0.77 (95% CI: 0.70-0.84), 3.5 (95% CI: 2.5-5.0), 0.26 (95% CI: 0.19-0.36), 14 (95% CI: 8-25) and 0.86 (95% CI: 0.82-0.88), respectively. Our subgroup analyses indicated miR-16 family assay was more appropriate in Asian populations.
conclusionsOur findings demonstrated that miR-16 family members have a relatively high value as promising biomarkers in diagnosing cancers. Nevertheless, the clinical application of miR-16 family profiling for cancers diagnosis still needs further large-scale studies and additional improvements of substantiation.
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