ReviewInternational journal of clinical and experimental medicine2015
The association between the rs11549465 polymorphism in the hif-1α gene and cancer risk: a meta-analysis.
Review in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Pooled it
- Unravelling the role of PRKCI and key-cancer related genes in breast cancer development and metastasis.Discover oncology · 2025Article
- mTOR pathway candidate genes and obesity interaction on breast cancer risk in black women from the Women's Circle of Health Study.Cancer causes & control : CCC · 2023Article
- Review
- Article
- Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis.Frontiers in oncology · 2018Article
- The role of HIF-1α in chemo-/radioresistant tumors.OncoTargets and therapy · 2018Review
- Association of breast cancer risk and the mTOR pathway in women of African ancestry in 'The Root' Consortium.Carcinogenesis · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe associations between hypoxia-inducible factor-1 alpha (HIF-1alpha) and clinicopathological characteristics of cancers have been evaluated in various studies, with the conflicting results. The common rs11549465 (1772C/T) genetic polymorphism has been reported to be functional and may contribute to genetic susceptibility to cancers. However, the association between rs11549465 (1772C/T) and cancer risk remains inconclusive.
methodsTo better understand the role of rs11549465 (1772C/T) polymorphism in global cancer, we conducted this comprehensive meta-analysis encompassing 7807 cases and 8633 controls.
resultsOverall, the rs11549465 (1772C/T) genetic polymorphism was associated with higher cancer risk, especially exists in Asians. In the stratified analysis, significant associations were found between the HIF-1 rs11549465 polymorphism and gynecologic cancer among Caucasian population. We observed that the TT genotype might modulate gynecologic cancer (OR=9.92 [2.15-45.66]) risk comparing with the CC genotype. Moreover, a significantly increased lung and breast cancer risk was found among Asian population comparing with Caucasian population. When stratified by study design, significantly elevated susceptibility to cancer was found among hospital -based studies.
conclusionsOur meta-analysis suggested that the HIF-1 rs11549465 (1772C/T) genetic polymorphism is significantly associated with higher risk among Asian population and lower risk among Caucasian population in breast and lung cancer, and this SNP was significantly associated with the gynecologic cancer among Caucasian population. The effect of the rs11549465 polymorphism on cancer especially exists in Asians.
Indexed as
Identifiers
25932084PMC4402731W2337829637What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.