ArticleG3 (Bethesda, Md.)2015
Composite Selection Signals for Complex Traits Exemplified Through Bovine Stature Using Multibreed Cohorts of European and African Bos taurus.
Article in G3 (Bethesda, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- A Meta-Assembly of Selection Signatures in Cattle.PloS one · 2016Pooled it
- Polygenic Prediction of Equestrian Sport Discipline Among Horses Bred for Jumping and Dressage.Animal genetics · 2026Article
- GWAS and selection signature analyses of whole-genome sequencing data identify genes associated with body size in Duolang sheep.Frontiers in veterinary science · 2026Article
- Genomic insights on the history and selection trajectories of the Comune di Sicilia goat.BMC genomic data · 2025Article
- Resequencing Composite Kazakh Whiteheaded Cattle: Insights into Ancestral Breed Contributions, Selection Signatures, and Candidate Genetic Variants.Animals : an open access journal from MDPI · 2025Article
- Pleomorphic adenoma gene1 in reproduction and implication for embryonic survival in cattle: a review.Journal of animal science · 2024Review
- Identification of Missense Variants Affecting Carcass Traits for Hanwoo Precision Breeding.Genes · 2023Article
- Identification of Genomic Signatures in Bullmastiff Dogs Using Composite Selection Signals Analysis of 23 Purebred Clades.Animals : an open access journal from MDPI · 2023Article
- Analysis of dog breed diversity using a composite selection index.Scientific reports · 2023Article
- Selection signatures for local and regional adaptation in Chinese Mongolian horse breeds reveal candidate genes for hoof health.BMC genomics · 2023Article
- Common protein-coding variants influence the racing phenotype in galloping racehorse breeds.Communications biology · 2022Article
- Exploring and Identifying Candidate Genes and Genomic Regions Related to Economically Important Traits in Hanwoo Cattle.Current issues in molecular biology · 2022Review
- Exploiting within-breed variability in the autochthonous Reggiana breed identified several candidate genes affecting pigmentation-related traits, stature and udder defects in cattle.Animal genetics · 2021Article
- Long-range linkage disequilibrium in French beef cattle breeds.Genetics, selection, evolution : GSE · 2021Article
- A Deletion Downstream of theAnimals : an open access journal from MDPI · 2020Article
- TheGenes · 2020Article
- Adaptive introgression from indicine cattle into white cattle breeds from Central Italy.Scientific reports · 2020Article
- Genomic inbreeding trends, influential sire lines and selection in the global Thoroughbred horse population.Scientific reports · 2020Article
- Assessing genomic diversity and signatures of selection in Original Braunvieh cattle using whole-genome sequencing data.BMC genomics · 2020Article
- Selection in Australian Thoroughbred horses acts on a locus associated with early two-year old speed.PloS one · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the evolution and molecular architecture of complex traits is important in domestic animals. Due to phenotypic selection, genomic regions develop unique patterns of genetic diversity called signatures of selection, which are challenging to detect, especially for complex polygenic traits. In this study, we applied the composite selection signals (CSS) method to investigate evidence of positive selection in a complex polygenic trait by examining stature in phenotypically diverse cattle comprising 47 European and 8 African Bos taurus breeds, utilizing a panel of 38,033 SNPs genotyped on 1106 animals. CSS were computed for phenotypic contrasts between multibreed cohorts of cattle by classifying the breeds according to their documented wither height to detect the candidate regions under selection. Using the CSS method, clusters of signatures of selection were detected at 26 regions (9 in European and 17 in African cohorts) on 13 bovine autosomes. Using comparative mapping information on human height, 30 candidate genes mapped at 12 selection regions (on 8 autosomes) could be linked to bovine stature diversity. Of these 12 candidate gene regions, three contained known genes (i.e., NCAPG-LCORL, FBP2-PTCH1, and PLAG1-CHCHD7) related to bovine stature, and nine were not previously described in cattle (five in European and four in African cohorts). Overall, this study demonstrates the utility of CSS coupled with strategies of combining multibreed datasets in the identification and discovery of genomic regions underlying complex traits. Characterization of multiple signatures of selection and their underlying candidate genes will elucidate the polygenic nature of stature across cattle breeds.
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