ArticleGenome biology and evolution2015
The evolutionary fate of alternatively spliced homologous exons after gene duplication.
Article in Genome biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Ancestral intronic splicing regulatory elements in the SCNbioRxiv : the preprint server for biology · 2026Article
- Toward a comprehensive profiling of alternative splicing proteoform structures, interactions and functions.Current opinion in structural biology · 2025Review
- Functional implications of paralog genes in polyglutamine spinocerebellar ataxias.Human genetics · 2023Review
- Origins and Evolution of Human Tandem Duplicated Exon Substitution Events.Genome biology and evolution · 2022Article
- Assessing conservation of alternative splicing with evolutionary splicing graphs.Genome research · 2021Article
- The divergence of alternative splicing between ohnologs in teleost fishes.BMC ecology and evolution · 2021Article
- Restriction of an intron size en route to endothermy.Nucleic acids research · 2021Article
- Biological impact of mutually exclusive exon switching.PLoS computational biology · 2021Article
- Integrative expression network analysis of microRNA and gene isoforms in sacred lotus.BMC genomics · 2020Article
- Isoforms of RNF128 Regulate the Stability of Mutant P53 in Barrett's Esophageal Cells.Gastroenterology · 2020Article
- The landscape of human mutually exclusive splicing.Molecular systems biology · 2017Article
- Copy number increases of transposable elements and protein-coding genes in an invasive fish of hybrid origin.Molecular ecology · 2017Article
- Conservation of alternative splicing in sodium channels reveals evolutionary focus on release from inactivation and structural insights into gating.The Journal of physiology · 2017Article
- Alternative splicing of U2AF1 reveals a shared repression mechanism for duplicated exons.Nucleic acids research · 2017Article
- The Evolutionary Relationship between Alternative Splicing and Gene Duplication.Frontiers in genetics · 2017Review
- The ribosome-engaged landscape of alternative splicing.Nature structural & molecular biology · 2016Article
- Article
- Alternatively Spliced Homologous Exons Have Ancient Origins and Are Highly Expressed at the Protein Level.PLoS computational biology · 2015Article
- The Rho GTPase Family Genes in Bivalvia Genomes: Sequence, Evolution and Expression Analysis.PloS one · 2015Article
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Authors and funding
3 authors.
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Abstract
Alternative splicing and gene duplication are the two main processes responsible for expanding protein functional diversity. Although gene duplication can generate new genes and alternative splicing can introduce variation through alternative gene products, the interplay between the two processes is complex and poorly understood. Here, we have carried out a study of the evolution of alternatively spliced exons after gene duplication to better understand the interaction between the two processes. We created a manually curated set of 97 human genes with mutually exclusively spliced homologous exons and analyzed the evolution of these exons across five distantly related vertebrates (lamprey, spotted gar, zebrafish, fugu, and coelacanth). Most of these exons had an ancient origin (more than 400 Ma). We found examples supporting two extreme evolutionary models for the behaviour of homologous axons after gene duplication. We observed 11 events in which gene duplication was accompanied by splice isoform separation, that is, each paralog specifically conserved just one distinct ancestral homologous exon. At other extreme, we identified genes in which the homologous exons were always conserved within paralogs, suggesting that the alternative splicing event cannot easily be separated from the function in these genes. That many homologous exons fall in between these two extremes highlights the diversity of biological systems and suggests that the subtle balance between alternative splicing and gene duplication is adjusted to the specific cellular context of each gene.
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