ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2015
Risk of fracture prevention in spina bifida patients: correlation between bone mineral density, vitamin D, and electrolyte values.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Analysis of Bone Mineral Density and Body Composition in Lower and Upper Limbs of Spina Bifida Patients Using DXA Scans.Progress in rehabilitation medicine · 2026Article
- Understanding Orthopaedic and Health-related Quality of Life Outcomes in Patients With Myelomeningocele Functional Classification 1 Spina Bifida in Relationship to Supportive Standing.Journal of the Pediatric Orthopaedic Society of North America · 2025Article
- Spina bifida and cardiorespiratory profile: the impact of leisure sport activities on physical fitness.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Quantitative Computed Tomography Assessment of Bone Deficits in Ambulatory Children and Adolescents with Spina Bifida: Importance of Puberty.JBMR plus · 2020Article
- Article
- Age-specific occurrence of pathological fractures in patients with spina bifida.European journal of pediatrics · 2020Article
- Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice.Scientific reports · 2018Article
- Fat-Bone Interactions in Adults With Spina Bifida.Journal of the Endocrine Society · 2017Article
- Low Energy Availability, Menstrual Dysfunction, and Low Bone Mineral Density in Individuals with a Disability: Implications for the Para Athlete Population.Sports medicine (Auckland, N.Z.) · 2017Review
- Obesity Prevention for Individuals with Spina Bifida.Current obesity reports · 2017Review
- Care for Adults with Spina Bifida: Current State and Future Directions.Topics in spinal cord injury rehabilitation · 2017Review
- Bone mineral density in pediatric patients with meningomyelocele.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of our study was to investigate the relationship between bone mineral density (BMD), vitamin D, and electrolyte blood values in patients with spina bifida, to find a possible therapeutic regimen and an intervention to reduce the risk of fractures in this population.
methodsBMD values were measured in 49 patients (32 females, 17 males; aged 14.1 ± 3.86 years; range 5-20 years) using dual-energy X-ray absorptiometry (DEXA) and were analyzed based on sex, the level of spinal involvement, vitamin D, and electrolyte values, physical activity, body mass index (BMI), and ambulatory status [patients were divided into three subgroups: full-time wheelchair (FTWC), limited ambulator (LA), and full-time ambulator (FTA)]. These data were analyzed considering sex-, age-, and BMD-matched values and compared with those of normal population.
resultsBMD was significantly lower in these patients compared with that in the general healthy population (Z-score: -1.2 ± 1.8); in particular, females had Z-score values significantly lower that of the males (Z-score: -2.43 ± 2.02; P < 0.0004). In FTWC subgroup, Z-score was lower than that of the other two subgroups (P < 0.009). Vitamin D values were significantly lower compared with those in the general healthy population (vitamin D spina bifida group: 14.6 ± 8.7 mg/dL; normal subjects: 35 ± 9.8 mg/dL; P < 0.001). Subjects with spina bifida showed hypophosphatemia (<3 mg/dL) because of the lower levels of vitamin D (3.1 ± 0.9 mg/dL; P < 0.001).
conclusionsSpina bifida patients showed lower BMD, vitamin D, and electrolyte values than the healthy population; hence, they have an increase risk of developing pathological fractures. Vitamin D supplementation for a longer time period could reduce this risk.
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