ArticleSystematic reviews2015
The burden of pertussis in low- and middle-income countries since the inception of the Expanded Programme on Immunization (EPI) in 1974: a systematic review protocol.
Article in Systematic reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Population-Based Pertussis Incidence and Risk Factors in Infants Less Than 6 Months in Nepal.Journal of the Pediatric Infectious Diseases Society · 2017Trial
- Is Pertussis Infection Neglected in China? Evidence from a Seroepidemiology Survey in Zhejiang, an Eastern Province of China.PloS one · 2016Trial
- Resurgence of pertussis: Epidemiological trends, contributing factors, challenges, and recommendations for vaccination and surveillance.Human vaccines & immunotherapeutics · 2025Review
- Assessing Immunization Coverage and the Negative Impact of Local Vaccine Production Cessation in Ecuador.Vaccines · 2025Article
- Review
- Type 5 secretion system antigens as vaccines against Gram-negative bacterial infections.NPJ vaccines · 2024Review
- Pertussis outbreak investigation in Likimsa-BokoreThe Pan African medical journal · 2024Article
- Laboratory Performance and Clinical Correlation of Real-time Polymerase Chain Reaction as a Diagnostic Test forOman medical journal · 2022Article
- Article
- Seroprevalence of pertussis in Madagascar and implications for vaccination.Epidemiology and infection · 2020Article
- Pertussis outbreak in southern Ethiopia: challenges of detection, management, and response.BMC public health · 2020Article
- Pertussis outbreak investigation in Janamora district, Amhara Regional State, Ethiopia: a case-control study.The Pan African medical journal · 2019Article
- Outbreak of suspected pertussis in Kaltungo, Gombe State, Northern Nigeria, 2015: the role of sub-optimum routine immunization coverage.The Pan African medical journal · 2019Article
- Assessing the Importance of Domestic Vaccine Manufacturing Centers: An Overview of Immunization Programs, Vaccine Manufacture, and Distribution.Frontiers in immunology · 2018Review
- Pertussis outbreak investigation of Mekdela district, South Wollo zone, Amhara region, North-West Ethiopia.BMC research notes · 2017Article
- Rapid Health Needs Assessment after Typhoons Bolaven and Tembin Using the Public Health Assessment for Emergency Response Toolkit in Paju and Jeju, Korea 2012.Journal of Korean medical science · 2017Article
- Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development.Clinical and vaccine immunology : CVI · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVaccine against pertussis has been in use for several decades. Despite the widespread use of pertussis vaccine, evidence shows resurgence of pertussis in high-income countries. Pertussis surveillance data is largely missing from low- and middle-income countries (LMICs). Without data on trends of pertussis, it is difficult to review and amend pertussis control policies in any country. We propose conducting a systematic review to evaluate the burden and trends of pertussis in LMICs since 1974. METHODS/
designCommon and medical subject heading (MeSH) terms for pertussis and LMICs will be used to search electronic databases for the relevant literature published between 1974 and December 2014. Only studies from LMICs that fulfils World Health Organisation (WHO) or CDC pertussis case definitions will be included. The studies must have a clear numerator and denominator in a well-defined population. Risk of bias will be evaluated by assessing all qualifying full-text articles for quality and eligibility using a modified quality score assessment tool. Standardised data extraction will be carried out after which descriptions of trends in the prevalence, incidence, as well as mortality rate and case fatality rate, will be done. Where sufficient data is available, the results will be stratified by age group, geography, location, vaccination and HIV status. DISCUSSION: The systematic review proposed by this protocol seeks to address the knowledge gap in the epidemiology of pertussis in LMICs for the first time. It is anticipated that the background epidemiological trends of pertussis in LMICs that our study will provide could be used in the planning for the control of pertussis. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42015015159.
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Registered trials
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