Trial reportGastrointestinal endoscopy2015
Linear-array EUS improves detection of pancreatic lesions in high-risk individuals: a randomized tandem study.
Trial report in Gastrointestinal endoscopy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Diagnostic value of integrating salivary and blood miRNAs for pancreatic cancer detection.Frontiers in oncology · 2025Pooled it
- Pooled it
- An international survey on the geographical differences in practice patterns and training of endoscopic ultrasound.Journal of translational internal medicine · 2025Article
- Advancements in Early Detection and Screening Strategies for Pancreatic Cancer: From Genetic Susceptibility to Novel Biomarkers.Journal of clinical medicine · 2024Review
- Chronic jetlag accelerates pancreatic neoplasia in conditionalChronobiology international · 2023Article
- Linear-array EUS improves the accuracy of predicting deep submucosal invasion in non-pedunculated rectal polyps compared with radial EUS: a prospective observational study.Surgical endoscopy · 2021Observational
- Review
- Value of endoscopic ultrasonography in the observation of the remnant pancreas after pancreatectomy.PloS one · 2021Article
- Role of endoscopic ultrasound in the screening and follow-up of high-risk individuals for familial pancreatic cancer.World journal of gastroenterology · 2019Review
- Results of surveillance in individuals at high-risk of pancreatic cancer: A systematic review and meta-analysis.United European gastroenterology journal · 2018Review
- Convex versus Radial Echoendoscopes - Comparison of Capability for Evaluating the Pancreatobiliary Junction.Clinical endoscopy · 2018Article
- Pancreatic Cancer Screening.Current treatment options in gastroenterology · 2017Review
- A Clinical Prediction Model to Assess Risk for Pancreatic Cancer Among Patients With New-Onset Diabetes.Gastroenterology · 2017Article
- Endoscopic ultrasonography.Gastrointestinal endoscopy · 2012Review
- Pancreatic duct imaging during aging.Endoscopic ultrasoundReview
- What should be known prior to performing EUS exams? (Part II).Endoscopic ultrasoundReview
- Evaluation of a new slim radial echoendoscope: A better option for an aging population.Endoscopic ultrasoundArticle
- What should be known prior to performing EUS?Endoscopic ultrasoundReview
- Prevalence of incidental pancreatic cyst on upper endoscopic ultrasound.Annals of gastroenterologyArticle
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundStudies comparing linear and radial EUS for the detection of pancreatic lesions in an asymptomatic population with increased risk for pancreatic cancer are lacking.
objectivesTo compare pancreatic lesion detection rates between radial and linear EUS and to determine the incremental diagnostic yield of a second EUS examination.
designRandomized controlled tandem study.
settingFive academic centers in the United States. PATIENTS: Asymptomatic high-risk individuals (HRIs) for pancreatic cancer undergoing screening EUS.
interventionsLinear and radial EUS performed in randomized order. MAIN OUTCOME MEASUREMENTS: Pancreatic lesion detection rate by type of EUS, miss rate of 1 EUS examination, and incremental diagnostic yield of a second EUS examination (second-pass effect).
resultsTwo hundred seventy-eight HRIs were enrolled, mean age 56 years (43.2%), and 90% were familial pancreatic cancer relatives. Two hundred twenty-four HRIs underwent tandem radial and linear EUS. When we used per-patient analysis, the overall prevalence of any pancreatic lesion was 45%. Overall, 16 of 224 HRIs (7.1%) had lesions missed during the initial EUS that were detected by the second EUS examination. The per-patient lesion miss rate was significantly greater for radial followed by linear EUS (9.8%) than for linear followed by radial EUS (4.5%) (P = .03). When we used per-lesion analysis, 73 of 109 lesions (67%) were detected by radial EUS and 99 of 120 lesions (82%) were detected by linear EUS (P < .001) during the first examination. The overall miss rate for a pancreatic lesion after 1 EUS examination was 47 of 229 (25%). The miss rate was significantly lower for linear EUS compared with radial EUS (17.5% vs 33.0%, P = .007). LIMITATIONS: Most detected pancreatic lesions were not confirmed by pathology.
conclusionLinear EUS detects more pancreatic lesions than radial EUS. There was a "second-pass effect" with additional lesions detected with a second EUS examination. This effect was significantly greater when linear EUS was used after an initial radial EUS examination.
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