Trial reportEuropean radiology2016
Performance of one-view breast tomosynthesis as a stand-alone breast cancer screening modality: results from the Malmö Breast Tomosynthesis Screening Trial, a population-based study.
Trial report in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 85 papers, 7 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Digital Breast Tomosynthesis - The Future Screening Tool for Breast Cancer?
Innovation in Mammography: Tomosynthesis Pathways
Who cites it
85 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Italian guidelines for the use of digital breast tomosynthesis in breast cancer screening programmes: GRADE-ADOLOPMENT of the European guidelines.La Radiologia medica · 2026Guideline
- Interval breast cancer rates for tomosynthesis vs mammography population screening: a systematic review and meta-analysis of prospective studies.European radiology · 2025Pooled it
- ESR Essentials: diagnostic work-up in patients with symptomatic breast disease-practice recommendations by the European Society of Breast Imaging.European radiology · 2025Guideline
- Accuracy and Effectiveness of Mammography versus Mammography and Tomosynthesis for Population-Based Breast Cancer Screening: A Systematic Review and Meta-Analysis.Scientific reports · 2020Pooled it
- [S3 guideline breast cancer: update on early detection, and mammography screening].Der Radiologe · 2019Guideline
- Digital breast tomosynthesis for breast cancer screening and diagnosis in women with dense breasts - a systematic review and meta-analysis.BMC cancer · 2018Pooled it
- Digital breast tomosynthesis (DBT): recommendations from the Italian College of Breast Radiologists (ICBR) by the Italian Society of Medical Radiology (SIRM) and the Italian Group for Mammography Screening (GISMa).La Radiologia medica · 2017Guideline
- Deep learning applied to two-dimensional color Doppler flow imaging ultrasound images significantly improves diagnostic performance in the classification of breast masses: a multicenter study.Chinese medical journal · 2021Trial
- Comparing two visualization protocols for tomosynthesis in screening: specificity and sensitivity of slabs versus planes plus slabs.European radiology · 2019Trial
- A randomized controlled trial of digital breast tomosynthesis versus digital mammography in population-based screening in Bergen: interim analysis of performance indicators from the To-Be trial.European radiology · 2019Trial
- Radiation dose with digital breast tomosynthesis compared to digital mammography: per-view analysis.European radiology · 2018Trial
- Accuracy and reading time for six strategies using digital breast tomosynthesis in women with mammographically negative dense breasts.European radiology · 2017Trial
- Measuring mammographic density: comparing a fully automated volumetric assessment versus European radiologists' qualitative classification.European radiology · 2016Trial
- False positives in breast cancer screening with one-view breast tomosynthesis: An analysis of findings leading to recall, work-up and biopsy rates in the Malmö Breast Tomosynthesis Screening Trial.European radiology · 2016Trial
- In Silico Digital Breast Tomosynthesis Dataset for the Comparative Analysis of Deep Learning Models in Tumor Segmentation.Journal of imaging informatics in medicine · 2026Article
- Enhancing Diagnostic Precision in Breast Cancer Detection: A Digital Breast Tomosynthesis Workshop Approach for Clinicians in the Southeast Asian Population.Asia-Pacific journal of clinical oncology · 2026Article
- Cancers not detected in one-view breast tomosynthesis screening-characteristics and reasons for non-detection.European radiology · 2025Article
- Review
- Estimation of the absorbed dose in simultaneous digital breast tomosynthesis and mechanical imaging.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- Comparing synthetic mammograms based on wide-angle digital breast tomosynthesis with digital mammograms.Journal of medical imaging (Bellingham, Wash.) · 2025Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the performance of one-view digital breast tomosynthesis (DBT) in breast cancer screening.
methodsThe Malmö Breast Tomosynthesis Screening Trial is a prospective population-based one-arm study with a planned inclusion of 15000 participants; a random sample of women aged 40-74 years eligible for the screening programme. This is an explorative analysis of the first half of the study population (n = 7500). Participants underwent one-view DBT and two-view digital mammography (DM), with independent double reading and scoring. Primary outcome measures were detection rate, recall rate and positive predictive value (PPV). McNemar's test with 95 % confidence intervals was used.
resultsBreast cancer was found in sixty-eight women. Of these, 46 cases were detected by both modalities, 21 by DBT alone and one by DM alone. The detection rate for one-view DBT was 8.9/1000 screens (95 % CI 6.9 to 11.3) and 6.3/1000 screens (4.6 to 8.3) for two-view DM (p < 0.0001). The recall rate after arbitration was 3.8 % (3.3 to 4.2) for DBT and 2.6 % (2.3 to 3.0) for DM (p < 0.0001). The PPV was 24 % for both DBT and DM.
conclusionOur results suggest that one-view DBT might be feasible as a stand-alone screening modality. KEY POINTS: One-view DBT as a stand-alone breast cancer screening modality has not been investigated. One-view DBT increased the cancer detection rate significantly. The recall rate increased significantly but was still low. Breast cancer screening with one-view DBT as a stand-alone modality seems feasible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.