ArticleEuropean radiology2015
Changes in structural lung disease in cystic fibrosis children over 4 years as evaluated by high-resolution computed tomography.
Article in European radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Radiologic progression with minimal functional decline in cystic fibrosis: Insights from a prospective study.World journal of radiology · 2026Article
- Structural and Functional Pulmonary MRI to Predict Pulmonary Exacerbations in Cystic Fibrosis.Chest · 2026Article
- Early structural lung changes in young children with cystic fibrosis: a call to action.Respiratory research & clinical practice · 2026Article
- Evolution of Lung Disease Studied by Computed Tomography in Adults with Cystic Fibrosis Treated with Elexacaftor/Tezacaftor/Ivacaftor.Journal of imaging · 2025Article
- Association Between Lung Parenchymal Attenuation in Computed Tomography and Airflow Limitation in Adults with Cystic Fibrosis.Diagnostics (Basel, Switzerland) · 2025Article
- Predictive value of computed tomography scoring systems evolution in adults with cystic fibrosis.European radiology · 2020Article
- Evaluation of high resolution computed tomography findings of cystic fibrosis.The Korean journal of internal medicine · 2019Article
- High-resolution computed tomography findings in young infants with cystic fibrosis detected by newborn screening.Clinics (Sao Paulo, Brazil) · 2019Article
- A semiquantitative MRI-Score can predict loss of lung function in patients with cystic fibrosis: Preliminary results.European radiology · 2018Article
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Authors and funding
7 authors.
Funding
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Abstract
objectivesTo compare the worsening of structural lung disease on high-resolution computed tomography (HRCT) with changes in spirometry results in cystic fibrosis (CF) patients, and analyse factors associated with the worsening of structural lung disease over time.
methodsA total of 31 CF subjects (mean age 11.03 ± 3.67 years old) were prospectively evaluated by two HRCT and spirometry tests performed 4 years apart. HRCT abnormalities were scored using the Bhalla scoring system. Comparisons between changes on HRCT and spirometry were made for all patients, and also for groups categorized by age, sex, genotypic alterations and lung obstruction.
resultsThe mean HRCT Bhalla scoring, forced expiratory volume in 1 s (FEV1 %pred.) and forced vital capacity (FVC %pred.) were 7.92 ± 3.59, 87.76 ± 20.52 and 96.54 ± 15.12, respectively. There was a significant deterioration in the Bhalla score (p < 0.01) and in certain categories: severity of bronchiectasis, peribronchial thickening, mucous plugging and bronchial divisions. Females had a more pronounced worsening of the Bhalla score than males (p = 0.048). No change over time was found in FEV1 and FVC. Only sex was associated with a deterioration in HRCT.
conclusionsHRCT Bhalla scoring changes statistically significantly over 4 years, but spirometry results do not. Worsening on HRCT is more evident in females. KEY POINTS: • HRCT Bhalla scoring changes significantly over 4 years, spirometry results do not. • Females experience faster respiratory deterioration than males. • Spirometry results are not associated with deterioration in HRCT.
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