ArticleMedicine2015
Comparison of acute respiratory events between asthma-COPD overlap syndrome and COPD patients: a population-based cohort study.
Article in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Asthma and chronic obstructive disease overlap (ACO), a systematic review of prevalence and co-morbidity factors based on diagnostic criteria.Journal of pharmaceutical policy and practice · 2026Review
- COPD Patients with Asthma Features in Vietnam: Prevalence and Suitability for Personalized Medicine.Journal of personalized medicine · 2023Article
- Syk-Targeted, a New 3-Arylbenzofuran Derivative EAPP-2 Blocks Airway Inflammation of Asthma-COPD Overlap in vivo and in vitro.Journal of inflammation research · 2021Article
- Enhanced risk of traumatic brain injury in patients with chronic obstructive pulmonary disease.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2020Article
- Associations among chronic obstructive pulmonary disease with asthma, pneumonia, and corticosteroid use in the general population.PloS one · 2020Observational
- Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries.The Journal of allergy and clinical immunology · 2019Article
- Statin use and Vital Organ Failure in Patients With Asthma-Chronic Obstructive Pulmonary Disease Overlap: A Time-Dependent Population-Based Study.Frontiers in pharmacology · 2019Article
- Statin for Tuberculosis and Pneumonia in Patients with Asthma⁻Chronic Pulmonary Disease Overlap Syndrome: A Time-Dependent Population-Based Cohort Study.Journal of clinical medicine · 2018Article
- Association of Arrhythmia in Patients with Cervical Spondylosis: A Nationwide Population-Based Cohort Study.Journal of clinical medicine · 2018Article
- Effect of the asthma-chronic obstructive pulmonary disease syndrome on the stroke, Parkinson's disease, and dementia: a national cohort study.Oncotarget · 2018Article
- Burden of asthma and COPD overlap (ACO) in Taiwan: a nationwide population-based study.BMC pulmonary medicine · 2018Article
- Article
- Asthma-COPD Overlap Shows Favorable Clinical Outcomes Compared to Pure COPD in a Korean COPD Cohort.Allergy, asthma & immunology research · 2017Article
- Asthma and Chronic Obstructive Pulmonary Disease Overlap: The Effect of Definitions on Measures of Burden.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2017Article
- Treatment trends in patients with asthma-COPD overlap syndrome in a COPD cohort: findings from a real-world survey.International journal of chronic obstructive pulmonary disease · 2017Article
- The relationship of depression in asthma-chronic obstructive pulmonary disease overlap syndrome.PloS one · 2017Article
- Current situation of asthma-COPD overlap syndrome (ACOS) in Chinese patients older than 40 years with airflow limitation: rationale and design for a multicenter, cross-sectional trial (study protocol).Journal of thoracic disease · 2016Article
- The Reemergence of the Asthma-COPD Overlap Syndrome: Characterizing a Syndrome in the Precision Medicine Era.Current allergy and asthma reports · 2016Review
- Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome: Nothing New Under the Sun.Immunology and allergy clinics of North America · 2016Review
- Why understanding the asthma chronic obstructive pulmonary disease overlap syndrome (ACOS) is important to the clinician.The Indian journal of medical research · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiologic studies investigating the differences in respiratory outcomes between asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) and chronic obstructive pulmonary disease (COPD) in an Asian population are lacking.We conducted a population-based cohort study to compare the incidence of acute respiratory events between ACOS and COPD cohorts in Taiwan. This study investigated the incidence of acute respiratory events, namely, pneumonia, acute exacerbation, acute respiratory failure, and cardiopulmonary arrest, in 8571 patients with physician-diagnosed ACOS between 2000 and 2007 from the Longitudinal Health Insurance Database. The comparison cohort comprised 17,088 COPD patients, frequency-matched according to age, sex, and the index-year. The duration of follow-up was measured for each patient from the index date to 5 years thereafter. We used univariable and multivariable Poisson regression models to analyze the risk of acute respiratory events by including the variables of sex, age, and comorbidity.The overall prevalence of ACOS was approximately 17.4% in patients with COPD. The prevalence of ACOS increased with age. During the 5-year follow-up, a greater incidence of acute respiratory events was observed in the ACOS cohort than in the COPD cohort (11.5 and 4.62, per 100 person-years, respectively) with an adjusted incidence rate ratio (IRR) of 1.72 (95% confidence interval [CI] = 1.63-1.81). Compared with the COPD cohort, the ACOS patients had a 1.13-fold adjusted IRR of pneumonia (95% CI = 1.07-1.20) and a 2.58-fold adjusted IRR of acute exacerbation (95% CI = 2.43-2.74). Clinicians should be aware of frequent exacerbation of ACOS and prescribe appropriate treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.