Evidence map›Paper›PMID 25929891›Full record

ArticleHNO2015

[Local allergic rhinitis to Alternaria alternata : Evidence for local IgE production exclusively in the nasal mucosa].

L Klimek, C Bardenhewer, M Spielhaupter, C Harai, K Becker, O Pfaar

Abstract readCase ReportsEnglish Abstract
PubMed Publisher
In one paragraph

Article in HNO, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Medicina (Kaunas, Lithuania) · 2025
    Review
  2. Article
  3. Review
  4. New microbes and new infections · 2019
    Article
  5. Article
  6. Local allergic rhinitis: evolution of concepts.Clinical and translational allergy · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

L KlimekZentrum für Rhinologie und Allergologie, An den Quellen 10, 65183, Wiesbaden, Deutschland, Ludger.Klimek@Allergiezentrum.org.
C Bardenhewer
M Spielhaupter
C Harai
K Becker
O Pfaar

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a subgroup of patients with symptoms of allergic rhinitis (AR), no systemic sensitization can be detected in skin tests or serum. These patients are considered to be afflicted with so-called "local allergic rhinitis" (LAR) with IgE-production exclusively at the site of the nasal mucosa. Patients without any positive allergy test results but seasonal (intermittent) or perennial (persistent) allergic symptoms were often misdiagnosed as having "non-allergic rhinitis" (NAR) in the past.However, there is evidence for a specific IgE-production in the nasal mucosa in these patients without systemic sensitization. The diagnosis of LAR is confirmed by clinical symptoms, the detection of specific IgE production in the nasal mucosa and/or nasal provocation tests.We report on two cases of LAR to Alternaria alternata with symptoms of persistent allergic rhinitis that have been diagnosed by positive allergenspecific nasal challenge tests and specific IgE determinations in nasal secretions.According to an actual literature research, this is the second report published on LAR caused by Alternaria alternata.

Indexed as

AdultAlternariaDiagnosis, DifferentialEvidence-Based MedicineFemaleHumansImmunoglobulin EMaleNasal MucosaNasal Provocation TestsRhinitis, AllergicImmunoglobulin E

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.