ArticleCortex; a journal devoted to the study of the nervous system and behavior2015
Auditory hedonic phenotypes in dementia: A behavioural and neuroanatomical analysis.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Differential insular cortex sub-regional atrophy in neurodegenerative diseases: a systematic review and meta-analysis.Brain imaging and behavior · 2020Pooled it
- Music processing in behavioural variant frontotemporal dementia and Alzheimer's disease: a functional MRI study.Brain communications · 2026Article
- Subjective time perception in dementia: a behavioural and neuroanatomical analysis.Brain communications · 2026Article
- Article
- Hearing impairment and dementia: cause, catalyst or consequence?Journal of neurology · 2025Review
- Clinical recognition of frontotemporal dementia with right anterior temporal predominance: A multicenter retrospective cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Primary progressive aphasia: six questions in search of an answer.Journal of neurology · 2024Review
- Musicality and social cognition in dementia: clinical and anatomical associations.Brain communications · 2024Article
- An attentional and working memory theory of hallucination vulnerability in frontotemporal dementia.Brain communications · 2024Article
- The architecture of abnormal reward behaviour in dementia: multimodal hedonic phenotypes and brain substrate.Brain communications · 2023Article
- Music appreciation phenotypes in patients with frontotemporal dementia: A pilot study.International journal of geriatric psychiatry · 2022Article
- The problematic syndrome of right temporal lobe atrophy: Unweaving the phenotypic rainbow.Frontiers in neurology · 2022Article
- Altered Intrinsic Regional Spontaneous Brain Activity in Patients With Severe Obesity and Meibomian Gland Dysfunction: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in human neuroscience · 2022Article
- Laughter as a paradigm of socio-emotional signal processing in dementia.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Anhedonia in Semantic Dementia-Exploring Right Hemispheric Contributions to the Loss of Pleasure.Brain sciences · 2021Article
- Hearing and dementia: from ears to brain.Brain : a journal of neurology · 2021Review
- Altered phobic reactions in frontotemporal dementia: A behavioural and neuroanatomical analysis.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- Connectivity of the human insula: A cortico-cortical evoked potential (CCEP) study.Cortex; a journal devoted to the study of the nervous system and behavior · 2019Article
- Primary progressive aphasia: a clinical approach.Journal of neurology · 2018Review
- Music models aberrant rule decoding and reward valuation in dementia.Social cognitive and affective neuroscience · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Patients with dementia may exhibit abnormally altered liking for environmental sounds and music but such altered auditory hedonic responses have not been studied systematically. Here we addressed this issue in a cohort of 73 patients representing major canonical dementia syndromes (behavioural variant frontotemporal dementia (bvFTD), semantic dementia (SD), progressive nonfluent aphasia (PNFA) amnestic Alzheimer's disease (AD)) using a semi-structured caregiver behavioural questionnaire and voxel-based morphometry (VBM) of patients' brain MR images. Behavioural responses signalling abnormal aversion to environmental sounds, aversion to music or heightened pleasure in music ('musicophilia') occurred in around half of the cohort but showed clear syndromic and genetic segregation, occurring in most patients with bvFTD but infrequently in PNFA and more commonly in association with MAPT than C9orf72 mutations. Aversion to sounds was the exclusive auditory phenotype in AD whereas more complex phenotypes including musicophilia were common in bvFTD and SD. Auditory hedonic alterations correlated with grey matter loss in a common, distributed, right-lateralised network including antero-mesial temporal lobe, insula, anterior cingulate and nucleus accumbens. Our findings suggest that abnormalities of auditory hedonic processing are a significant issue in common dementias. Sounds may constitute a novel probe of brain mechanisms for emotional salience coding that are targeted by neurodegenerative disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.