ArticleJournal of neurology2015
Prevalence and timeline of nonmotor symptoms in idiopathic rapid eye movement sleep behavior disorder.
Article in Journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Neuropsychological Changes in Isolated REM Sleep Behavior Disorder: A Systematic Review and Meta-analysis of Cross-sectional and Longitudinal Studies.Neuropsychology review · 2024Pooled it
- Use and Psychometric Properties of the MoCA in Spain: a Systematic Review With Meta-Analysis and Meta-Regression.Neuropsychology review · 2026Review
- Article
- The profile of gastrointestinal dysfunction in prodromal to late-stage Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Clinical and brain volumetric correlates of decreased DTI-ALPS, suggestive of local glymphatic dysfunction, in iRBD.NPJ Parkinson's disease · 2025Article
- Altered Intra- and Inter-Network Resting-State Functional Connectivity is Associated with Neuropsychological Functioning and Clinical Symptoms in Patients with Isolated Rapid Eye Movement Sleep Behavior Disorder.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Non-motor symptoms in prodromal Parkinson's disease are linked to reduced quality of life.Journal of Parkinson's disease · 2025Article
- Unraveling the Genetic Landscape of Neurological Disorders: Insights into Pathogenesis, Techniques for Variant Identification, and Therapeutic Approaches.International journal of molecular sciences · 2024Review
- Experimental Animal Models of Prodromal Parkinson's Disease.Journal of Parkinson's disease · 2024Review
- Neural Control of REM Sleep and Motor Atonia: Current Perspectives.Current neurology and neuroscience reports · 2023Review
- Clinical subtypes in patients with isolated REM sleep behaviour disorder.NPJ Parkinson's disease · 2023Article
- Rapid eye movement sleep behaviour disorder: Past, present, and future.Journal of sleep research · 2022Review
- Predictors of RBD progression and conversion to synucleinopathies.Current neurology and neuroscience reports · 2022Review
- Gastric Electrical Dysarrhythmia in Probable Rapid Eye Movement Sleep Behavior Disorder.Frontiers in neurology · 2021Article
- Animal Model for Prodromal Parkinson's Disease.International journal of molecular sciences · 2020Review
- Gut-Brain Axis: Potential Factors Involved in the Pathogenesis of Parkinson's Disease.Frontiers in neurology · 2020Review
- Nonmotor and Dopamine Transporter Change in REM Sleep Behavior Disorder by Olfactory Impairment.Journal of movement disorders · 2019Article
- REM sleep behavior disorder, autonomic dysfunction and synuclein-related neurodegeneration: where do we stand?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Review
- Rapid eye movement sleep behavior disorder and the link to alpha-synucleinopathies.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018Review
- Idiopathic REM sleep behaviour disorder and neurodegeneration - an update.Nature reviews. Neurology · 2018Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson disease (PD) patients may experience nonmotor symptoms (NMS) before Parkinsonism onset. Patients with idiopathic REM sleep behavior disorder (IRBD) eventually develop PD and may represent premotor PD. We aimed to evaluate the prevalence and perceived timeline of NMS in IRBD through validated scales and questionnaires used in PD research. In 44 IRBD patients and 40 matched controls, overall NMS evaluation was assessed by NMS questionnaire for Parkinson disease, olfaction by University of Pennsylvania Smell Identification Test, dysautonomia by scales for outcomes in Parkinson's disease-autonomic, constipation by Rome III criteria, depression by Hospital Anxiety and Depression Scale, cognitive impairment by Montreal cognitive assessment (MoCA) and hypersomnia by Epworth Sleepiness Scale. Patients were asked to report the perceived time of onset of hyposmia, constipation, and depression. Hyposmia (52.3 vs. 20.0 %, p = 0.002) and constipation (56.8 vs. 20.0 %, p = 0.001) were more frequent in patients than in controls. Patients reported more memory problems and showed a trend toward lower score in MoCA. Depression and hypersomnia were not more frequent in patients. The first symptom perceived was RBD in 38.6 % patients, hyposmia in 15.9 %, constipation in 11.4 %, and depression in 6.8 %. The temporal course of the NMS studied was heterogeneous. The three most common presentations were RBD followed by hyposmia; hyposmia followed by RBD; and hyposmia followed by RBD and constipation occurring at the same time span. IRBD patients frequently exhibit NMS that occur in premotor PD, particularly hyposmia and constipation. In IRBD, the perceived timeline of NMS is highly variable. This variability may suggest that pathological changes occurring in IRBD subjects are also heterogeneous and not restricted to the structures that regulate REM sleep.
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