ArticleGenes and immunity
Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women.
Article in Genes and immunity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Toll-like receptor variants and cervical Atopobium vaginae infection in women with pelvic inflammatory disease.American journal of reproductive immunology (New York, N.Y. : 1989) · 2018Trial
- Microbial regulators of physiological and reproductive health in women of reproductive age: their local, proximal and distal regulatory roles.NPJ biofilms and microbiomes · 2025Review
- Genetic predictors for bacterial vaginosis in women living with and at risk for HIV infection.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024Article
- Incidence, recurrence, and prevalence of bacterial vaginosis from acute to chronic HIV infection in a prospective cohort of women in South Africa.Annals of epidemiology · 2023Article
- Bacterial Vaginosis and Post-Operative Pelvic Infections.Healthcare (Basel, Switzerland) · 2023Review
- The Complex Link between the Female Genital Microbiota, Genital Infections, and Inflammation.Infection and immunity · 2021Review
- Germline Genetic Variants of Viral Entry and Innate Immunity May Influence Susceptibility to SARS-CoV-2 Infection: Toward a Polygenic Risk Score for Risk Stratification.Frontiers in immunology · 2021Review
- Article
- Microbiome factors in HPV-driven carcinogenesis and cancers.PLoS pathogens · 2020Review
- Immunopathology of Recurrent Vulvovaginal Infections: New Aspects and Research Directions.Frontiers in immunology · 2019Review
- Dysbiosis of the Vaginal Microbiota and Higher Vaginal Kynurenine/Tryptophan Ratio Reveals an Association withFrontiers in cellular and infection microbiology · 2018Article
- Bacterial species colonizing the vagina of healthy women are not associated with race.Anaerobe · 2017Article
- The vaginal microbiota, host defence and reproductive physiology.The Journal of physiology · 2017Review
- The Vaginal Microbiome: Current Understanding and Future Directions.The Journal of infectious diseases · 2016Article
- The Interplay of Host Immunity, Environment and the Risk of Bacterial Vaginosis and Associated Reproductive Health Outcomes.The Journal of infectious diseases · 2016Review
- Effect of smoking on the genetic makeup of toll-like receptors 2 and 6.OncoTargets and therapy · 2016Article
Corrections and comments
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Authors and funding
14 authors at 9 institutions in 4 countries.
Funding
Abstract
Bacterial vaginosis (BV) is a common vaginal syndrome associated with altered microflora that increases the risk of preterm delivery and acquisition of sexually transmitted diseases. The cause of BV is unknown although toll-like receptors (TLRs), that are central to innate immune responses, may be important. We evaluated associations between TLR SNPs and BV among HIV-1 infected and uninfected African women. Logistic regression was used to assess associations between SNPs (N=99) in TLRs 2-4, 7-9 and BV (as classified by Nugent's criteria). Among HIV-1 uninfected women, TLR7 rs5743737 and TLR7 rs1634323 were associated with a decreased risk of BV, whereas TLR7 rs179012 was associated with an increased risk. TLR2 SNP rs3804099 was associated with a decreased risk of BV among HIV-1 infected women. Our findings indicate that there may be differences in TLR association with BV among HIV-1 infected and HIV-1 uninfected women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.