ArticlePloS one2015
Flow regulation in coronary vascular tree: a model study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A microstructurally motivated framework to study autoregulation in the coronary circulation.The Journal of physiology · 2026Article
- A Microstructurally-Motivated Framework to Study Autoregulation in the Coronary Circulation.bioRxiv : the preprint server for biology · 2025Article
- Myocardial perfusion and flow reserve in the asynchronous heart: mechanistic insight from a computational model.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Effect of Different Classes of Antihypertensive Drugs on Arterial Stiffness.Current hypertension reports · 2023Review
- Review of cardiac-coronary interaction and insights from mathematical modeling.WIREs mechanisms of diseaseReview
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoronary blood flow can always be matched to the metabolic demand of the myocardium due to the regulation of vasoactive segments. Myocardial compressive forces play an important role in determining coronary blood flow but its impact on flow regulation is still unknown. The purpose of this study was to develop a coronary specified flow regulation model, which can integrate myocardial compressive forces and other identified regulation factors, to further investigate the coronary blood flow regulation behavior.
methodA theoretical coronary flow regulation model including the myogenic, shear-dependent and metabolic responses was developed. Myocardial compressive forces were included in the modified wall tension model. Shear-dependent response was estimated by using the experimental data from coronary circulation. Capillary density and basal oxygen consumption were specified to corresponding to those in coronary circulation. Zero flow pressure was also modeled by using a simplified capillary model.
resultPressure-flow relations predicted by the proposed model are consistent with previous experimental data. The predicted diameter changes in small arteries are in good agreement with experiment observations in adenosine infusion and inhibition of NO synthesis conditions. Results demonstrate that the myocardial compressive forces acting on the vessel wall would extend the auto-regulatory range by decreasing the myogenic tone at the given perfusion pressure.
conclusionsMyocardial compressive forces had great impact on coronary auto-regulation effect. The proposed model was proved to be consistent with experiment observations and can be employed to investigate the coronary blood flow regulation effect in physiological and pathophysiological conditions.
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