ArticleBMC plant biology2014
The plasticity of NBS resistance genes in sorghum is driven by multiple evolutionary processes.
Article in BMC plant biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 3 citations in OpenAlex.
- Pan-NLRome analysis uncovers genetic diversity and evolutionary dynamics among rice, maize and sorghum.The plant genome · 2026Article
- RNA-Seq analysis reveals early defense activation and responses associated with resistance to Fusarium thapsinum stalk infection in sorghum.BMC genomics · 2026Article
- Whole genome sequencing reveals transcriptional and translational elements potentially regulating biotic and abiotic stress responses in cowpea.Scientific reports · 2025Article
- Multi-genome comprehensive identification of SSR/SV and development of molecular markers database to serve Sorghum bicolor (L.) breeding.BMC genomic data · 2023Article
- PearMODB: a multiomics database for pear (Pyrus) genomics, genetics and breeding study.Database : the journal of biological databases and curation · 2023Article
- The role of gene presence-absence variations on genetic incompatibility in Asian rice.The New phytologist · 2023Article
- Genome-wide identification, characterization, and evolutionary analysis of NBS genes and their association with disease resistance in Musa spp.Functional & integrative genomics · 2022Article
- Multilevel evolution shapes the function of NB-LRR encoding genes in plant innate immunity.Frontiers in plant science · 2022Review
- Chromosome-scale assembly and analysis of biomass crop Miscanthus lutarioriparius genome.Nature communications · 2021Article
- Understanding the Sorghum-Frontiers in plant science · 2021Review
- Contrasting genetic variation and positive selection followed the divergence of NBS-encoding genes in Asian and European pears.BMC genomics · 2020Article
- Genome-Wide Association Mapping of Anthracnose (G3 (Bethesda, Md.) · 2019Article
- A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism.BMC genomics · 2019Article
- The Sorghum QTL Atlas: a powerful tool for trait dissection, comparative genomics and crop improvement.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- Connecting genome structural variation with complex traits in crop plants.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Review
- Genome wide association analysis of sorghum mini core lines regarding anthracnose, downy mildew, and head smut.PloS one · 2019Article
- Article
- Evaluation of Genetic Variation among Sorghum Varieties from Southwest China via Genome Resequencing.The plant genome · 2018Article
- Copy number variation and disease resistance in plants.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2017Review
- Rapid identification of candidate genes for resistance to tomato late blight disease using next-generation sequencing technologies.PloS one · 2017Article
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreased disease resistance is a key target of cereal breeding programs, with disease outbreaks continuing to threaten global food production, particularly in Africa. Of the disease resistance gene families, the nucleotide-binding site plus leucine-rich repeat (NBS-LRR) family is the most prevalent and ancient and is also one of the largest gene families known in plants. The sequence diversity in NBS-encoding genes was explored in sorghum, a critical food staple in Africa, with comparisons to rice and maize and with comparisons to fungal pathogen resistance QTL.
resultsIn sorghum, NBS-encoding genes had significantly higher diversity in comparison to non NBS-encoding genes and were significantly enriched in regions of the genome under purifying and balancing selection, both through domestication and improvement. Ancestral genes, pre-dating species divergence, were more abundant in regions with signatures of selection than in regions not under selection. Sorghum NBS-encoding genes were also significantly enriched in the regions of the genome containing fungal pathogen disease resistance QTL; with the diversity of the NBS-encoding genes influenced by the type of co-locating biotic stress resistance QTL.
conclusionsNBS-encoding genes are under strong selection pressure in sorghum, through the contrasting evolutionary processes of purifying and balancing selection. Such contrasting evolutionary processes have impacted ancestral genes more than species-specific genes. Fungal disease resistance hot-spots in the genome, with resistance against multiple pathogens, provides further insight into the mechanisms that cereals use in the "arms race" with rapidly evolving pathogens in addition to providing plant breeders with selection targets for fast-tracking the development of high performing varieties with more durable pathogen resistance.
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