Evidence map›Paper›PMID 25928355›Full record

ArticleCardiovascular diabetology2014

Obesity attenuates gender differences in cardiovascular mortality.

Xin Song, Adam G Tabák, Björn Zethelius, John S Yudkin, Stefan Söderberg, Tiina Laatikainen, Coen D A Stehouwer, Rachel Dankner, Pekka Jousilahti, Altan Onat and 6 more

Open access · goldAbstract read
In one paragraph

Article in Cardiovascular diabetology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 58 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Cardiovascular contributions to dementia: Examining sex differences and female-specific factors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. An Update on the Use of Wearable Devices in Men's Health.The world journal of men's health · 2023
    Review
  17. Obesity and the risk of cardiometabolic diseases.Nature reviews. Cardiology · 2023
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 12 countries.

Xin SongDepartment of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland. xin.song@helsinki.fi.
Adam G TabákDepartment of Epidemiology and Public Health, University College London, London, UK. a.tabak@ucl.ac.uk.
Björn ZetheliusDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden. bjorn.zethelius@pubcare.uu.se.
John S YudkinDepartment of Medicine, University College London, London, UK. j.yudkin@ucl.ac.uk.
Stefan SöderbergDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden. stefan.soderberg@medicin.umu.se.
Tiina LaatikainenDepartment of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland. tiina.laatikainen@thl.fi.
Coen D A StehouwerDepartment of Internal Medicine and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands. cda.stehouwer@mumc.nl.
Rachel DanknerUnit for Cardiovascular Epidemiology, The Gertner Institute, Sheba Medical Center, Tel Hashomer, Israel. RachelD@gertner.health.gov.il.
Pekka JousilahtiDepartment of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland. pekka.jousilahti@thl.fi.
Altan OnatDepartment of Cardiology, Cerrahpaşa Medical Faculty, Istanbul, Turkey. alt_onat@yahoo.com.tr.
Peter M NilssonDepartment of Clinical Sciences, Lund University, Malmö, Sweden. peter.nilsson@med.lu.se.
Ilhan SatmanIstanbul University, Istanbul Medical Faculty, Istanbul, Turkey. satmandiabet@gmail.com.
Olga VaccaroDepartment of Clinical Medicine and Surgery, Federico II University, Naples, Italy. ovaccaro@unina.it.
Jaakko TuomilehtoDepartment of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland. jaakko.tuomilehto@thl.fi.
Qing QiaoDepartment of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland. qing.qiao@helsinki.fi.
DECODE Study Group
Baker Heart and Diabetes Institute · AUMalmö University · SESemmelweis University · HUTel Aviv University · ILUniversität für Weiterbildung Krems · ATUniversity of Helsinki · FIFederico II University Hospital · ITFinnish Institute for Health and Welfare · FIUniversity of Eastern Finland · FIUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo estimate cardiovascular disease (CVD) mortality in relation to obesity and gender.

methodsData from 11 prospective cohorts from four European countries including 23 629 men and 21 965 women, aged 24 to 99 years, with a median follow-up of 7.9 years were analyzed. Hazards ratios (HR) for CVD mortality in relation to baseline body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) were estimated using Cox proportional hazards models with age as the timescale.

resultsMen had higher CVD mortality than women in all four BMI categories (<25.0, 25.0-29.9, 30.0-34.9 and ≥35.0 kg/m(2)). Compared with the lowest BMI category in women, multivariable adjusted HRs (95% confidence intervals) for higher BMI categories are 1.0 (0.8-1.4), 1.6 (1.1-2.1) and 2.8 (2.0-3.8) in women and 2.8 (2.2-3.6), 3.1 (2.5-3.9), 3.8 (2.9-4.9) and 5.4 (3.8-7.7) in men, respectively. Similar findings were observed for abdominal obesity defined by WC, WHR or WHtR. The gender difference was slightly smaller in obese than in non-obese individuals; but the interaction was statistically significant only between gender and WC (p = 0.02), and WHtR (p = 0.01). None of the interaction terms was significant among non-diabetic individuals.

conclusionsMen had higher CVD mortality than women across categories of anthropometric measures of obesity. The gender difference was attenuated in obese individuals, which warrants further investigation.

Indexed as

Sex CharacteristicsAdultAgedBody Mass IndexCardiovascular DiseasesFemaleHumansMaleMiddle AgedObesityProspective StudiesRisk FactorsWaist CircumferenceWaist-Hip Ratio

Identifiers

PMID25928355
PMCPMC4212094
OpenAlexW2142241703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.