ArticleRadiology2015
Endometrial Cancer: Combined MR Volumetry and Diffusion-weighted Imaging for Assessment of Myometrial and Lymphovascular Invasion and Tumor Grade.
Article in Radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
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Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it.
- ESGO/ESTRO/ESP Guidelines for the management of patients with endometrial carcinoma.Virchows Archiv : an international journal of pathology · 2021Guideline
- Apparent diffusion coefficient values on MRI as biomarkers for pre operative prediction of prognostic factors in endometrial cancer.Gynecologic oncology reports · 2026Article
- Preoperative Prediction of Lymphovascular Space Invasion in Endometrial Cancer Using Diffusion MRI-Derived Vessel Density.Korean journal of radiology · 2026Article
- Evaluating the utility of enhanced T1 mapping MR imaging in assessing depth of myometrial invasion and detecting DNA mismatch repair status in endometrial cancer: a pilot study.Abdominal radiology (New York) · 2026Article
- Preoperative risk assessment of endometrial cancer using histogram analysis of weighted and quantitative MRI images.Abdominal radiology (New York) · 2026Article
- Assessment of endometrial cancer with microcystic, elongated, and fragmented pattern invasion using multiparametric MRI.Abdominal radiology (New York) · 2025Article
- Integrative intratumoral and peritumoral radiomic model for predicting endometrial cancer grade.Oncology letters · 2025Article
- Diagnostic values of diffusion-weighted imaging and dynamic contrast-enhanced MRI in the pathological grading of adenoid cystic carcinoma.BMC medical imaging · 2025Article
- Prediction of grading of ovarian endometrioid carcinoma using conventional MRI features.Japanese journal of radiology · 2025Article
- The value of multi-sequence magnetic resonance imaging and whole-tumor apparent diffusion coefficient histogram analysis in differentiating p53 abnormal from non-p53 abnormal endometrial carcinoma.Frontiers in oncology · 2025Article
- Analysis of the Correlation between MRI Imaging Signs and Lymphovascular Space Invasion in Endometrial CancerCurrent medical imaging · 2025Article
- Multi-modality MRI radiomics phenotypes in intermediate-high risk endometrial cancer: correlations with histopathology and prognosis.Japanese journal of radiology · 2025Article
- Intratumoral and peritumoral multiparametric MRI-based radiomics nomogram for preoperative risk stratification in patients with endometrial cancer.Frontiers in oncology · 2025Article
- Diagnostic Value of MRI for Pelvic Lymph Node Extracapsular Invasion in Early-Stage Endometrial Carcinoma.International journal of women's health · 2025Article
- Analysis of the efficacy and safety of camrelizumab combined with chemotherapy for cervical cancer treatment.Frontiers in oncology · 2025Article
- Endometrial cancer risk stratification using MRI radiomics: corroborating with choline metabolism.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- MRI Radiomics Data Analysis for Differentiation between Malignant Mixed Müllerian Tumors and Endometrial Carcinoma.Cancers · 2024Article
- Article
- Review
- Predictive Value of Magnetic Resonance Imaging in Risk Stratification and Molecular Classification of Endometrial Cancer.Cancers · 2024Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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8 authors.
Funding
Abstract
purposeTo investigate magnetic resonance (MR) volumetry of endometrial tumors and its association with deep myometrial invasion, tumor grade, and lymphovascular invasion and to assess the value of apparent diffusion coefficient (ADC) histographic analysis of the whole tumor volume for prediction of tumor grade and lymphovascular invasion. MATERIALS AND
methodsThe institutional review board approved this retrospective study; patient consent was not required. Between May 2010 and May 2012, 70 women (mean age, 64 years; range, 24-91 years) with endometrial cancer underwent preoperative MR imaging, including axial oblique and sagittal T2-weighted, dynamic contrast material-enhanced, and diffusion-weighted imaging. Volumetry of the tumor and uterus was performed during the six sequences, with manual tracing of each section, and the tumor volume ratio (TVR) was calculated. ADC histograms were generated from pixel ADCs from the whole tumor volume. The threshold of TVR associated with myometrial invasion was assessed by using receiver operating characteristic curves. An independent sample Mann Whitney U test was used to compare differences in ADCs, skewness, and kurtosis between tumor grade and the presence of lymphovascular invasion.
resultsNo significant difference in tumor volume and TVR was found among the six MR imaging sequences (P = .95 and .86, respectively). A TVR greater than or equal to 25% allowed prediction of deep myometrial invasion with sensitivity of 100% and specificity of 93% (area under the curve, 0.96; 95% confidence interval: 0.86, 0.99) at axial oblique diffusion-weighted imaging. A TVR of greater than or equal to 25% was associated with grade 3 tumors (P = .0007) and with lymphovascular invasion (P < .0001). There was no significant difference in the ADCs between grades 1 and 2 tumors (P > .05). The minimum, 10th, 25th, 50th, 75th, and 90th percentile ADCs were significantly lower in grade 3 tumors than in grades 1 and 2 tumors (P < .02).
conclusionThe combination of whole tumor volume and ADC can be used for prediction of tumor grade, lymphovascular invasion, and depth of myometrial invasion.
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