Evidence map›Paper›PMID 25928142›Full record

ArticlePloS one2015

Sodium thiosulfate ameliorates oxidative stress and preserves renal function in hyperoxaluric rats.

Rakesh K Bijarnia, Matthias Bachtler, Prakash G Chandak, Harry van Goor, Andreas Pasch

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
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  6. Article
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  12. Use of Sodium Thiosulfate as an Otoprotectant in Patients With Cancer Treated With Platinum Compounds: A Review of the Literature.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Review
  13. Article
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  15. Intravenous N-Acetylcysteine to Prevent Cisplatin-Induced Hearing Loss in Children: A Nonrandomized Controlled Phase I Trial.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Rakesh K BijarniaDepartment of Nephrology, Hypertension and Clinical Pharmacology, University Hospital and University of Bern, Inselspital, Bern, Switzerland; Department of Clinical Research, University Hospital and University of Bern, Inselspital, Bern, Switzerland.
Matthias BachtlerDepartment of Nephrology, Hypertension and Clinical Pharmacology, University Hospital and University of Bern, Inselspital, Bern, Switzerland; Department of Clinical Research, University Hospital and University of Bern, Inselspital, Bern, Switzerland.
Prakash G ChandakDepartment of Nephrology, Hypertension and Clinical Pharmacology, University Hospital and University of Bern, Inselspital, Bern, Switzerland; Department of Clinical Research, University Hospital and University of Bern, Inselspital, Bern, Switzerland.
Harry van GoorDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Andreas PaschDepartment of Nephrology, Hypertension and Clinical Pharmacology, University Hospital and University of Bern, Inselspital, Bern, Switzerland; Department of Clinical Research, University Hospital and University of Bern, Inselspital, Bern, Switzerland.
University Hospital of Bern · CHUniversity Medical Center Groningen · NLUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHyperoxaluria causes crystal deposition in the kidney, which leads to oxidative stress and to injury and damage of the renal epithelium. Sodium thiosulfate (STS, Na2S2O3) is an anti-oxidant, which has been used in human medicine for decades. The effect of STS on hyperoxaluria-induced renal damage is not known.

methodsHyperoxaluria and renal injury were induced in healthy male Wistar rats by chronic exposure to ethylene glycol (EG, 0.75%) in the drinking water for 4 weeks. The treatment effects of STS, NaCl or Na2SO4 were compared. Furthermore, the effects of STS on oxalate-induced oxidative stress were investigated in vitro in renal LLC-PK1 cells.

resultsChronic EG exposure led to hyperoxaluria, oxidative stress, calcium oxalate crystalluria and crystal deposition in the kidneys. Whereas all tested compounds significantly reduced crystal load, only STS-treatment maintained tissue superoxide dismutase activity and urine 8-isoprostaglandin levels in vivo and preserved renal function. In in vitro studies, STS showed the ability to scavenge oxalate-induced ROS accumulation dose dependently, reduced cell-released hydrogen peroxide and preserved superoxide dismutase activity. As a mechanism explaining this finding, STS was able to directly inactivate hydrogen peroxide in cell-free experiments.

conclusionsSTS is an antioxidant, which preserves renal function in a chronic EG rat model. Its therapeutic use in oxidative-stress induced renal-failure should be considered.

Indexed as

AnimalsAntioxidantsDisease Models, AnimalHyperoxaluriaKidneyKidney Function TestsMaleOxidation-ReductionOxidative StressRatsReactive Oxygen SpeciesThiosulfatesAntioxidantsReactive Oxygen Speciessodium thiosulfateThiosulfates

Identifiers

PMID25928142
PMCPMC4415920
OpenAlexW2057475797

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.