ArticleBMC neuroscience2015
Simulation of alcohol action upon a detailed Purkinje neuron model and a simpler surrogate model that runs >400 times faster.
Article in BMC neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Biophysical modeling and experimental analysis of the dynamics of C. elegans body-wall muscle cells.PLoS computational biology · 2025Article
- Superconducting Bio-Inspired Au-Nanowire-Based Neurons.Nanomaterials (Basel, Switzerland) · 2022Article
- Phytochemical analysis and toxicological evaluation of the ethanolic Leaves extract ofSaudi journal of biological sciences · 2021Article
- An electrodiffusive neuron-extracellular-glia model for exploring the genesis of slow potentials in the brain.PLoS computational biology · 2021Article
- Resolving molecular contributions of ion channel noise to interspike interval variability through stochastic shielding.Biological cybernetics · 2021Article
- Molecular layer interneurons in the cerebellum encode for valence in associative learning.Nature communications · 2020Article
- An electrodiffusive, ion conserving Pinsky-Rinzel model with homeostatic mechanisms.PLoS computational biology · 2020Article
- The 40-year history of modeling active dendrites in cerebellar Purkinje cells: emergence of the first single cell "community model".Frontiers in computational neuroscience · 2015Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn approach to investigate brain function/dysfunction is to simulate neuron circuits on a computer. A problem, however, is that detailed neuron descriptions are computationally expensive and this handicaps the pursuit of realistic network investigations, where many neurons need to be simulated.
resultsWe confront this issue; we employ a novel reduction algorithm to produce a 2 compartment model of the cerebellar Purkinje neuron from a previously published, 1089 compartment model. It runs more than 400 times faster and retains the electrical behavior of the full model. So, it is more suitable for inclusion in large network models, where computational power is a limiting issue. We show the utility of this reduced model by demonstrating that it can replicate the full model's response to alcohol, which can in turn reproduce experimental recordings from Purkinje neurons following alcohol application.
conclusionsWe show that alcohol may modulate Purkinje neuron firing by an inhibition of their sodium-potassium pumps. We suggest that this action, upon cerebellar Purkinje neurons, is how alcohol ingestion can corrupt motor co-ordination. In this way, we relate events on the molecular scale to the level of behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.