ArticleGenome biology2015
The histone methyltransferase SDG8 mediates the epigenetic modification of light and carbon responsive genes in plants.
Article in Genome biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 121 citations in OpenAlex.
- Positional grammar of transcription factor binding partitions developmental and stress-response regulation in plants.Nature communications · 2026Article
- Somatic mobility of transposons is explosive and shaped by distinct integration biases in Arabidopsis thaliana.Genome biology · 2026Article
- Epigenetically regulated transcriptional repressor, BASIC PENTACYSTEINE1 (BPC1) acts together with polycomb repressive complex 2 (PRC2) to suppress camalexin biosynthesis in Arabidopsis.Plant molecular biology · 2026Article
- Uncovering the early and conserved molecular mechanisms of root nitrogen foraging in model and crops.BMC genomics · 2026Article
- H3K36 methyltransferase SDG102 enhances salt tolerance by altering the methylation level of genes in maize (Zea mays L.).BMC plant biology · 2026Article
- Physiological and Molecular Mechanisms of Nitrogen Regulation on Grain Quality in Cereal Crops at Later Stages.International journal of molecular sciences · 2026Review
- Plant-specific function of H3K9me3 as a permissive chromatin mark during Arabidopsis seed germination.Frontiers in plant science · 2026Article
- Functional Analysis of MaizePlants (Basel, Switzerland) · 2025Article
- A Brief Overview of the Epigenetic Regulatory Mechanisms in Plants.International journal of molecular sciences · 2025Review
- Functions and Mechanisms of Histone Modifications in Plants.Annual review of plant biology · 2025Review
- H3K36 methylation stamps transcription resistive to preserve development in plants.Nature plants · 2025Article
- Organ-specific characteristics govern the relationship between histone code dynamics and transcriptional reprogramming during nitrogen response in tomato.Communications biology · 2023Article
- Chromosome-Wide Distribution and Characterization of H3K36me3 and H3K27Ac in the Marine Model DiatomPlants (Basel, Switzerland) · 2023Article
- Epigenetic Regulation of Nitrogen Signaling and Adaptation in Plants.Plants (Basel, Switzerland) · 2023Review
- CG hypermethylation of theHorticulture research · 2023Article
- Physiological, epigenetic, and proteomic responses in Pfaffia glomerata growth in vitro under salt stress and 5-azacytidine.Protoplasma · 2023Article
- A Green Light to Switch on Genes: Revisiting Trithorax on Plants.Plants (Basel, Switzerland) · 2022Review
- Redox status of the plant cell determines epigenetic modifications under abiotic stress conditions and during developmental processes.Journal of advanced research · 2022Review
- Light, chromatin, action: nuclear events regulating light signaling in Arabidopsis.The New phytologist · 2022Review
- Transcription-coupled and epigenome-encoded mechanisms direct H3K4 methylation.Nature communications · 2022Article
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundHistone methylation modifies the epigenetic state of target genes to regulate gene expression in the context of developmental and environmental changes. Previously, we used a positive genetic screen to identify an Arabidopsis mutant, cli186, which was impaired in carbon and light signaling. Here, we report a deletion of the Arabidopsis histone methyltransferase SDG8 in this mutant (renamed sdg8-5), which provides a unique opportunity to study the global function of a specific histone methyltransferase within a multicellular organism.
resultsTo assess the specific role of SDG8, we examine how the global histone methylation patterns and transcriptome were altered in the sdg8-5 deletion mutant compared to wild type, within the context of transient light and carbon treatments. Our results reveal that the sdg8 deletion is associated with a significant reduction of H3K36me3, preferentially towards the 3' end of the gene body, accompanied by a reduction in gene expression. We uncover 728 direct targets of SDG8 that have altered methylation in the sdg8-5 mutant and are also bound by SDG8. As a group, this set of SDG8 targets is enriched in specific biological processes including defense, photosynthesis, nutrient metabolism and energy metabolism. Importantly, 64% of these SDG8 targets are responsive to light and/or carbon signals.
conclusionsThe histone methyltransferase SDG8 functions to regulate the H3K36 methylation of histones associated with gene bodies in Arabidopsis. The H3K36me3 mark in turn is associated with high-level expression of a specific set of light and/or carbon responsive genes involved in photosynthesis, metabolism and energy production.
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