Evidence map›Paper›PMID 25927905›Full record

ArticleBMC infectious diseases2015

Immunolocalization of the 29 kDa Schistosoma haematobium species-specific antigen: a potential diagnostic marker for urinary schistosomiasis.

Uri S Markakpo, George E Armah, Julius N Fobil, Richard H Asmah, Isaac Anim-Baidoo, Alfred K Dodoo, Parnor Madjitey, Edward E Essuman, Somei Kojima, Kwabena M Bosompem

Open access · goldAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Uri S MarkakpoDepartment of Biological, Environmental and Occupational Health Sciences, School of Public Health, College of Health Sciences, University of Ghana, P. O. Box LG13, Legon, Accra, Ghana. umckakpo@noguchi.mimcom.org.
George E ArmahNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P. O. Box LG581, Legon, Accra, Ghana. garmah@noguchi.mimcom.org.
Julius N FobilDepartment of Biological, Environmental and Occupational Health Sciences, School of Public Health, College of Health Sciences, University of Ghana, P. O. Box LG13, Legon, Accra, Ghana. jfobil@yahoo.com.
Richard H AsmahSchool of Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana. rhasmah@chs.edu.gh.
Isaac Anim-BaidooSchool of Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana. iabaidoo@chs.edu.gh.
Alfred K DodooNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P. O. Box LG581, Legon, Accra, Ghana. adodoo@noguchi.mimcom.org.
Parnor MadjiteyDepartment of Biological, Environmental and Occupational Health Sciences, School of Public Health, College of Health Sciences, University of Ghana, P. O. Box LG13, Legon, Accra, Ghana. pmardjitey@gmail.com.
Edward E EssumanDepartment of Biological, Environmental and Occupational Health Sciences, School of Public Health, College of Health Sciences, University of Ghana, P. O. Box LG13, Legon, Accra, Ghana. eddenco@yahoo.com.
Somei KojimaAsian Centre for International Parasite Control, Mahidol University, Bankok, Thailand. kojima@ims.tsukuba.ac.jp.
Kwabena M BosompemNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P. O. Box LG581, Legon, Accra, Ghana. kbosompem@noguchi.mimcom.org.
University of Ghana · GHNoguchi Memorial Institute for Medical Research · GHMahidol University · THUniversity of Health and Allied Sciences · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe 29 kDa Schistosoma haematobium species-specific antigen (ShSSA) is of remarkable interest in the diagnosis of urinary schistosomiasis although it had not been fully characterized.

methodTo determine the biological importance of ShSSA in S. haematobium and pathogenesis of the disease, we immunolocalized ShSSA in schistosome eggshells, miracidia and adult worm sections using indirect fluorescent antibody test (IFAT).

resultsShSSA was strongly immunolocalized in the schistosome eggshells, selective regions of the miracidia body and walls of internal organs such as oviduct, ovary, vitelline duct and gut of the adult worm.

conclusionThe strong immunolocalization of ShSSA in schistosome eggshells and adult worm internal organs suggests that the antigens involved in the pathogenesis of urinary schistosomiasis could have originated from the eggs and adult worms of the parasite. The findings also indicate that ShSSA may play a mechanical protective role in the survival of the parasite.

Indexed as

AnimalsAntigens, HelminthBiomarkersCross-Sectional StudiesFemaleFluorescent Antibody Technique, IndirectGhanaHumansMalePredictive Value of TestsSchistosoma haematobiumSchistosomiasis haematobiaSpecies SpecificityUrinalysisAntigens, HelminthBiomarkers

Identifiers

PMID25927905
PMCPMC4416236
OpenAlexW2138712426

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.