Evidence map›Paper›PMID 25927900›Full record

ReviewMolecules (Basel, Switzerland)2015

Investigation of Carbohydrate Recognition via Computer Simulation.

Quentin R Johnson, Richard J Lindsay, Loukas Petridis, Tongye Shen

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Quentin R JohnsonUT-ORNL Graduate School of Genome Science and Technology, Knoxville, TN 37996, USA. qjohnso3@utk.edu.
Richard J LindsayDepartment of Biochemistry and Cellular & Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA. rlindsa2@utk.edu.
Loukas PetridisCenter for Molecular Biophysics, Oak Ridge National Lab, Oak Ridge, TN 37830, USA. petridisl@ornl.gov.
Tongye ShenDepartment of Biochemistry and Cellular & Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA. tshen@utk.edu.
University of Tennessee at Knoxville · USOak Ridge National Laboratory · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbohydrate recognition by proteins, such as lectins and other (bio)molecules, can be essential for many biological functions. Recently, interest has arisen due to potential protein and drug design and future bioengineering applications. A quantitative measurement of carbohydrate-protein interaction is thus important for the full characterization of sugar recognition. We focus on the aspect of utilizing computer simulations and biophysical models to evaluate the strength and specificity of carbohydrate recognition in this review. With increasing computational resources, better algorithms and refined modeling parameters, using state-of-the-art supercomputers to calculate the strength of the interaction between molecules has become increasingly mainstream. We review the current state of this technique and its successful applications for studying protein-sugar interactions in recent years.

Indexed as

Molecular Dynamics SimulationThermodynamicsAlgorithmsBinding SitesCarbohydrate MetabolismCarbohydratesDrug DesignLectinsModels, BiologicalSignal TransductionCarbohydratesLectins

Identifiers

PMID25927900
PMCPMC6272577
OpenAlexW2066028025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.