Trial reportPloS one2015
Determination of Zygosity in Adult Chinese Twins Using the 450K Methylation Array versus Questionnaire Data.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Genetic Regulation of DNA Methylation and Its Mediating Role in Blood Pressure: A Genome-Wide Twin Study.MedComm · 2026Article
- Revealing genetic foundations underlying cardiometabolic traits: integrating twin and GWAS data in Asian populations.International journal of obesity (2005) · 2026Article
- Association between cardiovascular health and epigenetic aging: a twin study.Clinical epigenetics · 2026Article
- Predicting Zygosity based on physical similarity of twin pairs with the aid of machine learning methods.BMC medical informatics and decision making · 2025Article
- Longitudinal changes in the genetic and environmental influences on DNA methylation linked to obesity measures: a 5-year twin study.Molecular biomedicine · 2025Article
- Child Mental Health Research in Low- and Middle-Income Countries: A Twin-Family Feasibility Study in Nigeria.Behavior genetics · 2025Article
- Genetic influences on the association between DNA methylation and obesity measures: insights from a twin study design.Cell & bioscience · 2025Article
- [Association between DNA methylation clock and obesity-related indicators: A longitudinal twin study].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025Article
- Trends of genetic contributions on epigenetic clocks and related methylation sites with aging: A population-based adult twin study.Aging cell · 2025Article
- The metabolic signature of blood lipids: a causal inference study using twins.Journal of lipid research · 2024Article
- Five years of change in adult twins: longitudinal changes of genetic and environmental influence on epigenetic clocks.BMC medicine · 2024Article
- Association between epigenetic age and type 2 diabetes mellitus or glycemic traits: A longitudinal twin study.Aging cell · 2024Article
- Age effect on the shared etiology of glycemic traits and serum lipids: evidence from a Chinese twin study.Journal of endocrinological investigation · 2024Article
- Article
- Is the Pandemic Wearing Us Out? A Cross-Sectional Study of the Prevalence of Fatigue in Adult Twins without Previous SARS-CoV-2 Infection.Journal of clinical medicine · 2022Article
- Temporal associations between leukocytes DNA methylation and blood lipids: a longitudinal study.Clinical epigenetics · 2022Article
- Genetics, shared environment, or individual experience? A cross-sectional study of the health status following SARS-CoV-2 infection in monozygotic and dizygotic twins.Frontiers in psychiatry · 2022Article
- Combined healthy lifestyle score and risk of epigenetic aging: a discordant monozygotic twin study.Aging · 2021Article
- Associations of Metabolic/Obesity Phenotypes with Insulin Resistance and C-Reactive Protein: Results from the CNTR Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- The Roles of Genetic and Early-Life Environmental Factors in the Association Between Overweight or Obesity and Hypertension: A Population-Based Twin Study.Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have shown that both single nucleotide polymorphisms (SNPs) and questionnaires-based method can be used for twin zygosity determination, but few validation studies have been conducted using Chinese populations. In the current study, we recruited 192 same sex Chinese adult twin pairs to evaluate the validity of using genetic markers-based method and questionnaire-based method in zygosity determination. We considered the relatedness analysis based on more than 0.6 million SNPs genotyping as the golden standards for zygosity determination. After quality control, qualified twins were left for relatedness analysis based on identical by descent calculation. Then those same sex twin pairs were included in the zygosity questionnaire validation analysis. Logistic regression model was applied to assess the discriminant ability of age, sex and the three questions in zygosity determination. Leave one out cross-validation was used as a measurement of internal validation. The results of zygosity determination based on 65 SNPs in 450k methylation array were all consistent with genotyping. Age, gender, questions of appearance confused by strangers and previously perceived zygosity consisted of the most predictable model with a consistency rate of 0.8698, cross validation predictive error of 0.1347. For twin studies with genotyping and\or 450k methylation array, there would be no need to conduct other zygosity testing for the sake of costs consideration.
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