ArticleBreast cancer research : BCR2014
A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer.
Article in Breast cancer research : BCR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Regulation of breast cancer metastasis signaling by miRNAs.Cancer metastasis reviews · 2020Review
- Histone Deacetylase-3 Modification of MicroRNA-31 Promotes Cell Proliferation and Aerobic Glycolysis in Breast Cancer and Is Predictive of Poor Prognosis.Journal of breast cancer · 2018Article
- Clinical importance of the EMSY gene expression and polymorphisms in ovarian cancer.Oncotarget · 2018Article
- Overexpression of suppressive microRNAs, miR-30a and miR-200c are associated with improved survival of breast cancer patients.Scientific reports · 2017Article
- MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists.Nature communications · 2017Article
- Systematic discovery of novel eukaryotic transcriptional regulators using sequence homology independent prediction.BMC genomics · 2017Article
- Function and regulation of microRNA-31 in development and disease.Molecular reproduction and development · 2016Review
- A novel double-negative feedback loop between miR-489 and the HER2-SHP2-MAPK signaling axis regulates breast cancer cell proliferation and tumor growth.Oncotarget · 2016Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
miR-31 is well known as an anti-metastatic microRNA (miRNA) in the context of breast cancer. However, to date the mechanism of regulation of this miRNA has yet to be elucidated. The recent publication by Viré et al. in Molecular Cell demonstrates for the first time that one mechanism of regulation of miR-31 is through the putative oncogene EMSY, whose amplification in breast cancer patients correlates with reduced expression of the miRNA. This regulation is dependent on the DNA-binding transcription factor ETS-1 which recruits EMSY and the histone demethylase KDM5B to the miR-31 promoter, thus repressing its transcription.
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