Evidence map›Paper›PMID 25927426›Full record

ArticleBMC medicine2015

Recognizing and managing sepsis: what needs to be done?

Donald M Yealy, David T Huang, Anthony Delaney, Marian Knight, Adrienne G Randolph, Ron Daniels, Tim Nutbeam

Open access · goldAbstract read
In one paragraph

Article in BMC medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. The impact of telehealth in sepsis care: A systematic review.Journal of telemedicine and telecare · 2025
    Pooled it
  2. Article
  3. Observational
  4. Article
  5. Observational
  6. lncRNA NEAT1 aggravates sepsis-induced lung injury by regulating the miR-27a/PTEN axis.Laboratory investigation; a journal of technical methods and pathology · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Article
  17. Article
  18. Article
  19. Current aspects in sepsis approach. Turning things around.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2018
    Review
  20. Activity and Circadian Rhythm of Sepsis Patients in the Intensive Care Unit.... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Donald M YealyUniversity of Pittsburgh, Pittsburgh, PA, USA. yeaslydm@upmc.edu.
David T HuangUniversity of Pittsburgh, Pittsburgh, PA, USA. huangdt@upmc.edu.
Anthony DelaneyMalcolm Fisher Department of Intensive Care Medicine, Level 6, Acute Services Building, Royal North Shore Hospital, Reserve Road, St. Leonards, Sydney, NSW, 2065, Australia. adelaney@med.usyd.edu.au.
Marian KnightNational Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Old Rd Campus, Oxford, OX3 7LF, UK. marian.knight@npeu.ox.ac.uk.
Adrienne G RandolphDepartment of Anesthesia, Perioperative and Pain Medicine, Critical Care Division, Boston Children's Hospital, Bader 634, 300 Longwood Avenue, Boston, MA, 02115, USA. adrienne.randolph@childrens.harvard.edu.
Ron DanielsHeart of England NHS Foundation Trust, UK Sepsis Trust, Sutton Coldfield, West Midlands, B72 1NE, UK. ron@sepsistrust.org.
Tim NutbeamDepartment of Emergency Medicine, Derriford Hospital, Plymouth, DL6 8DH, UK. timnutbeam@nhs.net.
University of Pittsburgh · USBoston Children's Hospital · USDerriford Hospital · GBHeart of England NHS Foundation Trust · GBRoyal North Shore Hospital · AUUniversity of Oxford · GB

Funding

Department of Health NIHR-RP-011-032Department of Health RP-PG-0608-10038
6 · The paper itself

Abstract

Sepsis is associated with significant morbidity and mortality if not promptly recognized and treated. Since the development of early goal-directed therapy, mortality rates have decreased, but sepsis remains a major cause of death in patients arriving at the emergency department or staying in hospital. In this forum article, we asked clinicians and researchers with expertise in sepsis care to discuss the importance of rapid detection and treatment of the condition, as well as special considerations in different patient groups.

Indexed as

AdultChildFemaleHumansMaleSepsis

Identifiers

PMID25927426
PMCPMC4410741
OpenAlexW2165857770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.