Evidence map›Paper›PMID 25927335›Full record

ArticleBMC infectious diseases2014

The tuberculin skin test in school going adolescents in South India: associations of socio-demographic and clinical characteristics with TST positivity and non-response.

Dharma Rao Uppada, Sumithra Selvam, Nelson Jesuraj, Sean Bennett, Suzanne Verver, Harleen M S Grewal, Mario Vaz, TB Trials Study Group

Open access · goldAbstract read
In one paragraph

Article in BMC infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Dharma Rao UppadaSt. John's Emmaus TB Research Initiatives (SETRI), Palamaner, India. druppadajan13@gmail.com.
Sumithra SelvamSt. John's Research Institute, Bangalore, India. sumithrars@sjri.res.in.
Nelson JesurajSt. John's Emmaus TB Research Initiatives (SETRI), Palamaner, India. nelsonsjri@gmail.com.
Sean BennettGilead Sciences, Inc., Foster City, CA, USA. sean.bennett@hotmail.com.
Suzanne VerverKNCV Tuberculosis Foundation, The Hague, The Netherlands. suzanne.verver@kncvtbc.org.
Harleen M S GrewalDepartment of Clinical Science, Infection, Faculty of Medicine and Dentistry, University of Bergen, N-5021, Bergen, Norway. Harleen.Grewal@k2.uib.no.
Mario VazPhysiology and Head of Health and Humanities, St. John's Medical College and St. John's Research Institute, Bangalore, India. mariovaz@sjri.res.in.
TB Trials Study Group
Gilead Sciences (United States) · USSt.John's Medical College Hospital · INSt. John's National Academy of Health Sciences · INTuBerculosis Vaccine Initiative · NLUniversity of Bergen · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndia has generally used 1 TU purified protein derivative (PPD) as opposed to 2 TU PPD globally, limiting comparisons. It is important to assess latent TB infection in adolescents given that they may be a target group for new post-exposure TB vaccines. The aim of this study is to describe the pattern and associations of tuberculin skin test (TST) responses (0.1 ml 2 TU) in adolescents in South India.

methods6643 school-going adolescents (11 to <18 years) underwent TST. Trained tuberculin reader made the reading visit between 48 and 96 hours after the skin test

resultsOf 6608 available TST results, 9% had 0 mm, and 12% ≥10 mm responses. The proportion of TST positive (≥10 mm) was higher among older children, boys, those with a history of TB contact and reported BCG immunization Those with no TST response (0 mm) included younger participants (<14 years), those whose mothers were illiterate and those with a recent history of weight loss. Those of a higher socio-economic status (houses with brick walls, LPG gas as cooking fuel) and those with a visible BCG scar were less likely to be non-responders.

conclusionProportion of non-responders was lower than elsewhere in the world. Proportion of TST positivity was higher in those already exposed to TB and in children who had been BCG immunized, with a zero response more likely in younger adolescents and those with recent weight loss.

Indexed as

StudentsTuberculin TestAdolescentBCG VaccineChildFemaleHumansIndiaMaleSocial ClassTuberculosisVaccinationWeight LossBCG Vaccine

Identifiers

PMID25927335
PMCPMC4243729
OpenAlexW2064888233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.