ArticleScientific reports2015
Raman spectroscopic sensing of carbonate intercalation in breast microcalcifications at stereotactic biopsy.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnosis accuracy of Raman spectroscopy in the diagnosis of breast cancer: a meta-analysis.Analytical and bioanalytical chemistry · 2022Pooled it
- Artificial intelligence in breast surgery: Current applications, challenges, and future perspectives.The Journal of international medical research · 2026Review
- Use of artificial intelligence in breast surgery: a narrative review.Gland surgery · 2024Review
- Exploration of utility of combined optical photothermal infrared and Raman imaging for investigating the chemical composition of microcalcifications in breast cancer.Analytical methods : advancing methods and applications · 2023Article
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis.Theranostics · 2022Article
- Article
- Raman spectroscopy determination of the mineral characteristics of microcalcifications in breast cancer: a way towards an improved screening approach.Oncotarget · 2021Article
- Raman spectroscopy and artificial intelligence to predict the Bayesian probability of breast cancer.Scientific reports · 2021Article
- Quantitative chemical imaging of breast calcifications in association with neoplastic processes.Theranostics · 2020Article
- Raman Spectroscopy for Rapid Evaluation of Surgical Margins during Breast Cancer Lumpectomy.Scientific reports · 2019Article
- Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment.Cancer research · 2019Article
- X-ray scanning microscopies of microcalcifications in abdominal aortic and popliteal artery aneurysms.IUCrJ · 2019Article
- Mapping the genetic basis of breast microcalcifications and their role in metastasis.Scientific reports · 2018Article
- Raman active components of skin cancer.Biomedical optics express · 2017Article
- Three-Dimensional Printing of Bone Extracellular Matrix for Craniofacial Regeneration.ACS biomaterials science & engineering · 2016Article
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Authors and funding
8 authors.
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Abstract
Microcalcifications are an early mammographic sign of breast cancer and frequent target for stereotactic biopsy. Despite their indisputable value, microcalcifications, particularly of the type II variety that are comprised of calcium hydroxyapatite deposits, remain one of the least understood disease markers. Here we employed Raman spectroscopy to elucidate the relationship between pathogenicity of breast lesions in fresh biopsy cores and composition of type II microcalcifications. Using a chemometric model of chemical-morphological constituents, acquired Raman spectra were translated to characterize chemical makeup of the lesions. We find that increase in carbonate intercalation in the hydroxyapatite lattice can be reliably employed to differentiate benign from malignant lesions, with algorithms based only on carbonate and cytoplasmic protein content exhibiting excellent negative predictive value (93-98%). Our findings highlight the importance of calcium carbonate, an underrated constituent of microcalcifications, as a spectroscopic marker in breast pathology evaluation and pave the way for improved biopsy guidance.
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