ArticleBMC pulmonary medicine2015
Adherence to treatment in children and adolescents with cystic fibrosis: a cross-sectional, multi-method study investigating the influence of beliefs about treatment and parental depressive symptoms.
Article in BMC pulmonary medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07088614 (Effectiveness of Remote Respiratory Physiotherapy Using a Digital Platform on the Frequency of Exacerbations, Lung Function and Quality of Life, Assessed Before and After 6 Months of Intervention, in Children Aged 6-18 Years With Cystic Fibrosis at Dr. Luis Calvo Mackenna Hospital), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Remote Respiratory Physiotherapy Using a Digital Platform on the Frequency of Exacerbations, Lung Function and Quality of Life, Assessed Before and After 6 Months of Intervention, in Children Aged 6-18 Years With Cystic Fibrosis at Dr. Luis Calvo Mackenna Hospital: a Pre-experimental Study.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Interventions for improving adherence to airway clearance treatment and exercise in people with cystic fibrosis.The Cochrane database of systematic reviews · 2023Pooled it
- Mobile direct observation of therapy (MDOT) - A rapid systematic review and pilot study in children with asthma.PloS one · 2018Pooled it
- Effects of music therapy as an adjunct to chest physiotherapy in children with cystic fibrosis: A randomized controlled trial.PloS one · 2020Trial
- Assessment of pMDI inhaler technique in children and adolescents with cystic fibrosis.Jornal de pediatria · 2026Article
- Hybrid Tele-Rehabilitation in the Management of Pediatric Chronic Suppurative Lung Diseases: Study Protocol for a Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2026Article
- "I know that exercise is very good for me": perception of pediatric patients with cystic fibrosis about physical exercise program.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2026Article
- Association of depressive symptoms with sweat chloride variability and medication possession ratio during long-term Elexacaftor/Tezacaftor/Ivacaftor therapy in adolescents and young adults with cystic fibrosis.Frontiers in pediatrics · 2026Article
- Mapping Perceived Impact, Facilitators and Barriers of Cystic Fibrosis Management in Children and Adolescents: A Qualitative Study From the Parents' Perspective.Scandinavian journal of caring sciences · 2025Article
- The Role of Psychological Interventions in Enhancing Quality of Life for Patients with Cystic Fibrosis-A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Understanding beliefs about elexacaftor-tezacaftor-ivacaftor therapy in adults living with cystic fibrosis.BMJ open respiratory research · 2025Article
- Therapies Used by Children With Primary Ciliary Dyskinesia: A Natural History Study.Pediatric pulmonology · 2025Observational
- Effects of a Tailored Home-Based Exercise Program, "KidMove", on Children with Cystic Fibrosis: A Quasi-Experimental Study.Healthcare (Basel, Switzerland) · 2024Article
- Telerehabilitation in Children and Adolescents with Cystic Fibrosis: A Scoping Review.Healthcare (Basel, Switzerland) · 2024Article
- Prevalence and factors associated with medication adherence in children with central precocious puberty: a cross-sectional study.Frontiers in pharmacology · 2023Article
- Higher hydroxyurea adherence among young adults with sickle cell disease compared to children and adolescents.Annals of medicine · 2022Article
- Clinical and Genetic Characterisation of Cystic Fibrosis Patients in Latvia: A Twenty-Five-Year Experience.Diagnostics (Basel, Switzerland) · 2022Article
- Prevalence and predictors of non-adherence to short-term antibiotics: A population-based survey.PloS one · 2022Article
- Adherence to cystic fibrosis transmembrane conductance regulator (CFTR) modulators: analysis of a national specialty pharmacy database.Journal of drug assessment · 2021Article
- It's not all about inhaled treatment: challenges with oral therapy in paediatric respiratory medicine.Breathe (Sheffield, England) · 2021Review
- Decreased Wait Time and Increased Satisfaction With Bedside Pancreatic Enzyme Dosing for the Inpatient Adolescent With Cystic Fibrosis: A Quality Improvement Project Comparing Enzyme Self-Administration to Nurse Administration.Journal of patient experience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdherence to treatment is often reported to be low in children with cystic fibrosis. Adherence in cystic fibrosis is an important research area and more research is needed to better understand family barriers to adherence in order for clinicians to provide appropriate intervention. The aim of this study was to evaluate adherence to enzyme supplements, vitamins and chest physiotherapy in children with cystic fibrosis and to determine if any modifiable risk factors are associated with adherence.
methodsA sample of 100 children (≤18 years) with cystic fibrosis (44 male; median [range] 10.1 [0.2-18.6] years) and their parents were recruited to the study from the Northern Ireland Paediatric Cystic Fibrosis Centre. Adherence to enzyme supplements, vitamins and chest physiotherapy was assessed using a multi-method approach including; Medication Adherence Report Scale, pharmacy prescription refill data and general practitioner prescription issue data. Beliefs about treatments were assessed using refined versions of the Beliefs about Medicines Questionnaire-specific. Parental depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale.
resultsUsing the multi-method approach 72% of children were classified as low-adherers to enzyme supplements, 59% low-adherers to vitamins and 49% low-adherers to chest physiotherapy. Variations in adherence were observed between measurement methods, treatments and respondents. Parental necessity beliefs and child age were significant independent predictors of child adherence to enzyme supplements and chest physiotherapy, but parental depressive symptoms were not found to be predictive of adherence.
conclusionsChild age and parental beliefs about treatments should be taken into account by clinicians when addressing adherence at routine clinic appointments. Low adherence is more likely to occur in older children, whereas, better adherence to cystic fibrosis therapies is more likely in children whose parents strongly believe the treatments are necessary. The necessity of treatments should be reinforced regularly to both parents and children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.