Evidence map›Paper›PMID 25927271›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2015

Intestinal perforation in very preterm neonates: risk factors and outcomes.

J Shah, N Singhal, O da Silva, N Rouvinez-Bouali, M Seshia, S K Lee, P S Shah, Canadian Neonatal Network

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Necrotizing enterocolitis with gastric perforation in a 24-day old preterm neonate.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026
    Article
  6. Necrotizing enterocolitis.Nature reviews. Disease primers · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Article
  13. Article
  14. Blood absolute monocyte count trends in preterm infants with suspected necrotizing enterocolitis: an adjunct tool for diagnosis?Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Prophylactic indomethacin, antenatal betamethasone, and the risk of intestinal perforation in infants <28 weeks' gestation.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

J ShahDepartment of Pediatrics, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
N SinghalDepartment of Pediatrics, Foothills Hospital, University of Calgary, Calgary, AB, Canada.
O da SilvaDepartment of Pediatrics, London Health Sciences Center, University of Western Ontario, London, ON, Canada.
N Rouvinez-BoualiDepartment of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa University, Ottawa, ON, Canada.
M SeshiaDepartment of Pediatrics, Winnipeg Health Sciences Center, University of Manitoba, Winnipeg, MB, Canada.
S K Lee1] Department of Pediatrics, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada [2] Maternal-Infant Care Research Centre, Mount Sinai Hospital, Toronto, ON, Canada.
P S Shah1] Department of Pediatrics, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada [2] Maternal-Infant Care Research Centre, Mount Sinai Hospital, Toronto, ON, Canada.
Canadian Neonatal Network

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

objectiveTo compare neonatal outcomes of preterm infants (born at <32 weeks' gestation) with focal/spontaneous intestinal perforation (SIP), necrotizing enterocolitis (NEC)-related perforation, NEC without perforation or no NEC/perforation. STUDY

designRetrospective cohort study of 17,426 infants admitted to Canadian neonatal intensive care units during 2010 to 2013. The primary outcome was a composite of mortality or morbidity (bronchopulmonary dysplasia, severe retinopathy, periventricular leukomalacia or nosocomial infection). Association of intestinal perforation with neonatal outcome was evaluated using multivariate logistic regression.

resultSIP was present in 178 (1.0%) infants, NEC-related perforation in 246 (1.4%) and NEC without perforation in 538 (3.1%). Any intestinal perforation was associated with higher odds of the composite outcome (adjusted odds ratio (AOR): 8.21, 95% confidence interval (95% CI) 6.26 to 10.8); however, the odds were significantly lower for focal/SIP compared with NEC-related perforation (AOR: 0.29, 95% CI 0.17 to 0.51).

conclusionOf the two types of intestinal perforation, NEC-related perforation was associated with the highest risk of an adverse neonatal outcome.

Indexed as

Infant, Extremely PrematureCanadaCross InfectionEnterocolitis, NecrotizingFemaleGestational AgeHumansInfantInfant MortalityInfant, NewbornInfant, Premature, DiseasesIntensive Care Units, NeonatalIntestinal PerforationLogistic ModelsMaleMultivariate Analysis

Identifiers

PMID25927271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.