ArticlePloS one2015
Extremely sparse olfactory inputs are sufficient to mediate innate aversion in Drosophila.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
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- Alternative strategies based on transgenic Drosophila melanogaster for the functional characterization of insect Ionotropic Receptors.Biological research · 2025Article
- Olfactory responses of the variegated fruit fly, Phortica variegata, an emerging vector of the zoonotic eyeworm Thelazia callipaeda, to ecologically relevant volatiles.Parasites & vectors · 2025Article
- The conserved IR75 subfamily mediates carboxylic acid detection in insects of public health and agricultural importance.Journal of insect science (Online) · 2025Review
- Response Plasticity ofInternational journal of molecular sciences · 2024Article
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- Identification of multiple odorant receptors essential for pyrethrum repellency in Drosophila melanogaster.PLoS genetics · 2021Article
- The Structure and Function of Ionotropic Receptors inFrontiers in molecular neuroscience · 2020Review
- Primacy coding facilitates effective odor discrimination when receptor sensitivities are tuned.PLoS computational biology · 2019Article
- A GAL80 Collection To Inhibit GAL4 Transgenes inG3 (Bethesda, Md.) · 2018Article
- Olfactory Neurons and Brain Centers Directing Oviposition Decisions in Drosophila.Cell reports · 2018Article
- Olfactory Mechanisms for Discovery of Odorants to Reduce Insect-Host Contact.Journal of chemical ecology · 2016Review
- Olfactory Behaviors Assayed by Computer Tracking Of Drosophila in a Four-quadrant Olfactometer.Journal of visualized experiments : JoVE · 2016Article
- Behavior Reveals Selective Summation and Max Pooling among Olfactory Processing Channels.Neuron · 2016Article
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- Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Innate attraction and aversion to odorants are observed throughout the animal kingdom, but how olfactory circuits encode such valences is not well understood, despite extensive anatomical and functional knowledge. In Drosophila melanogaster, ~50 types of olfactory receptor neurons (ORNs) each express a unique receptor gene, and relay information to a cognate type of projection neurons (PNs). To examine the extent to which the population activity of ORNs is required for olfactory behavior, we developed a genetic strategy to block all ORN outputs, and then to restore output in specific types. Unlike attraction, aversion was unaffected by simultaneous silencing of many ORNs, and even single ORN types previously shown to convey neutral valence sufficed to mediate aversion. Thus, aversion may rely on specific activity patterns in individual ORNs rather than the number or identity of activated ORNs. ORN activity is relayed into the brain by downstream circuits, with excitatory PNs (ePN) representing a major output. We found that silencing the majority of ePNs did not affect aversion, even when ePNs directly downstream of single restored ORN types were silenced. Our data demonstrate the robustness of olfactory aversion, and suggest that its circuit mechanism is qualitatively different from attraction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.