ArticleJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale2014
Differential expression of transforming growth factor-beta in benign vs. papillary thyroid cancer nodules; a potential diagnostic tool?
Article in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Prognostic significance of tumor-associated macrophages in breast cancer: a meta-analysis of the literature.Oncotarget · 2017Pooled it
- Hashimoto's thyroiditis both promotes and protects against papillary thyroid cancer.Frontiers in endocrinology · 2026Review
- Mechanisms underlying the promotion of papillary thyroid carcinoma occurrence and progression by Hashimoto's thyroiditis.Frontiers in endocrinology · 2025Review
- TGFBR3 inhibits progression of papillary thyroid cancer by inhibiting the PI3K/AKT pathway and EMT.Endocrine connections · 2024Article
- Widefield polarization-resolved second harmonic generation imaging of entire thyroid nodule sections for the detection of capsular invasion.Biomedical optics express · 2024Article
- Papillary thyroid cancer with Hashimoto's thyroiditis attenuates the tumour aggressiveness through the up-regulation of E-cadherin and TGF-β expression.Clinical and experimental medicine · 2023Article
- Impact of transforming growth factor beta 1 on normal and thyroid cancer side population cells.Endocrine · 2022Article
- Clinical utility ofArchives of endocrinology and metabolism · 2021Article
- Article
- Plasma miR-323 as a Biomarker for Screening Papillary Thyroid Cancer From Healthy Controls.Frontiers in medicine · 2020Article
- The Immune Landscape of Thyroid Cancer in the Context of Immune Checkpoint Inhibition.International journal of molecular sciences · 2019Review
- Serum miR-22 may be a biomarker for papillary thyroid cancer.Oncology letters · 2019Article
- Functional assessment of the BMPR2 gene in lymphoblastoid cell lines from Graves' disease patients.Journal of cellular and molecular medicine · 2018Article
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Authors and funding
8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThyroid nodules are common, but only 5% of nodules are found to be malignant. In North America, the incidence of thyroid cancer is increasing. Fine needle aspirate (FNA) biopsy is the diagnostic test of choice. Unfortunately, up to 20% of FNAs are non-diagnostic. A specific molecular marker for thyroid cancer is desirable. Evidence suggests that cell signaling through transforming growth factor beta (TGF-β) is important in the development of thyroid cancer. We sought to compare the expression of TGF-β in malignant and benign thyroid nodules.
methodsFrom 2008-present, thyroid nodule tissue from thyroidectomy specimens was prospectively collected and stored at -80°C. RNA extraction and reverse transcription was performed on 47 samples (24 papillary thyroid cancer and 23 benign nodules). Quantitative PCR using SYBR green was performed to detect TGF-β-1 and -2. Resulting CT values were normalized against β-actin. Gene expression was calculated using the 2(-ΔC)T method.
resultsA significantly greater expression of TGF-β1 (p < 0.0001) was detected in the group of malignant thyroid nodules compared to benign nodules. There was no difference in the expression of TGF-β2 (p = 0.4735) between the two groups.
conclusionsIn this study, we demonstrated that expression of TGF-β1 but not TGF-β2 is significantly increased in papillary thyroid cancer compared to benign thyroid nodules. This may serve as a potential diagnostic marker for papillary thyroid cancer.
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