Evidence map›Paper›PMID 25927024›Full record

ArticleJournal of reproduction & infertility

Female reproductive hormones and biomarkers of oxidative stress in genital Chlamydia infection in tubal factor infertility.

Augusta Chinyere Nsonwu-Anyanwu, Mabel Ayebantoyo Charles-Davies, Victor Olusegun Taiwo, Bin Li, Anthony Alabar Oni, Folashade Adenike Bello

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of reproduction & infertility. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Alterations of Vaginal Microbiota in Women With Infertility andFrontiers in cellular and infection microbiology · 2021
    Article
  5. The complexity of interactions between female sex hormones andCurrent clinical microbiology reports · 2019
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Augusta Chinyere Nsonwu-AnyanwuMedical Lab., Science Department, College of Medical Sciences, University of Calabar, Calabar, Nigeria.
Mabel Ayebantoyo Charles-DaviesDepartment of Chemical Pathology, University of Ibadan, Ibadan, Nigeria.
Victor Olusegun TaiwoDepartment of Veterinary Pathology, University of Ibadan, Ibadan, Nigeria.
Bin LiUnit of Molecular Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Anthony Alabar OniDepartment of Medical Microbiology & Parasitology, University of Ibadan, Ibadan, Nigeria.
Folashade Adenike BelloDepartment of Obstetrics and Gynaecology, University of Ibadan, Ibadan, Nigeria.
University of Ibadan · NGChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenital Chlamydia infection (GCI) and the associated pathologies have been implicated in tubal infertility. Though the actual pathologic mechanisms are still uncertain, oxidative stress and other factors have been implicated. The purpose of the study was to determine the possible contribution of female reproductive hormones and biomarkers of oxidative stress in genital Chlamydial infection to tubal occlusion.

methodsThis prospective case control study was carried out by recruiting 150 age matched women grouped into infertile Chlamydia positive women (n = 50), fertile Chlamydia positive women (n = 50) and fertile Chlamydia negative women as controls (n = 50). High vaginal swabs and endocervical swabs were collected for screening Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, Treponema pallidum, Staphylococcus aureus, and Candida albicans. Sera were collected for estimation of Chlamydia trachomatis antibody, female reproductive hormones [Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), Oestradiol (E2), Progesterone (P4), Prolactin (PRL)] and biomarkers of oxidative stress [Total Antioxidant Capacity (TAC) and 8-hydroxyl-2-deoxyguanosine (8-OHdG)] by enzyme immunoassay (EIA). Data were analyzed using chi square, analysis of variance and LSD Post hoc to determine mean differences at p = 0.05.

resultsAmong women with GCI, higher levels of LH and 8-OHdG were observed in infertile Chlamydia positive women compared to fertile Chlamydia positive women (p < 0.05). Higher levels of LH and 8-OHdG and lower TAC levels were observed in infertile Chlamydia positive women compared to fertile Chlamydia negative controls (p < 0.05).

conclusionMechanisms including oxidative DNA damage and reduced antioxidant capacity may be involved in the pathology of Chlamydia induced tubal damage.

Indexed as

Chlamydia trachomatisFemale infertilityHormonesOxidative stressTubal obstruction

Identifiers

PMID25927024
PMCPMC4386090
OpenAlexW2133377802

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.