Evidence map›Paper›PMID 25926972›Full record

ArticleMedical gas research2015

Hyperbaric oxygen therapy ameliorates TNBS-induced acute distal colitis in rats.

Rogério S Parra, Alexandre H Lopes, Eleonora U Carreira, Marley R Feitosa, Fernando Q Cunha, Sérgio B Garcia, Thiago M Cunha, José J R da Rocha, Omar Féres

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical gas research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Effects of Hyperbaric Oxygen Therapy forJournal of the anus, rectum and colon · 2023
    Article
  7. Article
  8. Article
  9. A Review of Hyperbaric Oxygen Therapy for Inflammatory Bowel Disease.International journal of general medicine · 2021
    Review
  10. Article
  11. Article
  12. Article
  13. New Beginnings forMedical gas research · 2016
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. What's new inMedical gas research
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Rogério S ParraDivision of Coloproctology, Department of Surgery and Anatomy. Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP Brazil.
Alexandre H LopesDepartment of Pharmacology, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão Preto, SP Brazil.
Eleonora U CarreiraDepartment of Pharmacology, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão Preto, SP Brazil.
Marley R FeitosaDivision of Coloproctology, Department of Surgery and Anatomy. Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP Brazil.
Fernando Q CunhaDepartment of Pharmacology, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão Preto, SP Brazil.
Sérgio B GarciaDepartment of Pathology, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão Preto, SP Brazil.
Thiago M CunhaDepartment of Pharmacology, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão Preto, SP Brazil.
José J R da RochaDivision of Coloproctology, Department of Surgery and Anatomy. Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP Brazil.
Omar FéresDivision of Coloproctology, Department of Surgery and Anatomy. Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP Brazil.
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study investigated the therapeutic effects of hyperbaric oxygen in experimental acute distal colitis focusing on its effect on the production of pro-inflammatory cytokines, nitric oxide and hypoxia-inducible factor 1alpha.

methodsColitis was induced with a rectal infusion of 150 mg/kg of TNBS under anesthesia with Ketamine (50 mg/kg) and Xylazine (10 mg/kg). Control animals received only rectal saline. After colitis induction, animals were subjected to two sessions of hyperbaric oxygen and were then euthanized. The distal intestine was resected for macroscopic analysis, determination of myeloperoxidase activity, western-blotting analyses of inducible nitric oxide synthase and cyclooxygenase-2 expression and immunohistochemical analysis of hypoxia-inducible factor 1alpha and cyclooxygenase-2. Cytokines levels in the distal intestine were measured using an enzyme-linked immunosorbent assay.

resultsHyperbaric oxygen therapy attenuated the severity of acute distal colitis, with reduced macroscopic damage score. This effect was associated with prevention in the increase of pro-inflammatory cytokine production; myeloperoxidase activity, in the expression of inducible nitric oxide synthase and cyclooxygenase-2. Finally, hyperbaric oxygen inhibited the acute distal colitis-induced up-regulation of hypoxia-inducible factor 1alpha.

conclusionsThe results indicate that hyperbaric oxygen attenuates the severity of acute distal colitis through the down-regulation of pro-inflammatory events.

Indexed as

CytokinesExperimental colitisHyperbaric oxygenHypoxiaInflammatory bowel diseases

Identifiers

PMID25926972
PMCPMC4414439
OpenAlexW2046852765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.