ReviewGastroenterology and hepatology from bed to bench2015
Seronegative celiac disease: where is the specific setting?
Review in Gastroenterology and hepatology from bed to bench, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Acquired Motor-Sensory Polyneuropathy as a Rare Manifestation of Seronegative Celiac Disease in an Adolescent Boy.Annals of Indian Academy of Neurology · 2026Article
- Clinical and Histopathological Profile of Adults with Celiac Disease at Diagnosis and on a Gluten-Free Diet: A Cross-Sectional Observational Study.Clinics and practice · 2026Article
- Challenges in the Pediatric Celiac Disease Diagnosis: An Up-to-Date Review.Diagnostics (Basel, Switzerland) · 2025Review
- Non-celiac Enteropathies.Current gastroenterology reports · 2025Review
- A new algorithm for coeliac disease based on the 'long forgotten' TCRγδHistopathology · 2025Article
- What does not look like celiac disease and instead it is.Gastroenterology and hepatology from bed to bench · 2023Article
- Seronegative Celiac Disease in Patients with Isolated Refractory Dyspepsia and Gastroesophageal Reflux Disease.Gut and liver · 2022Article
- Celiac Disease Revisited.GE Portuguese journal of gastroenterology · 2022Review
- Expression of Selected Genes and Circulating microRNAs in Patients with Celiac Disease.Medicina (Kaunas, Lithuania) · 2022Article
- Serologic diagnosis of celiac disease: May it be suitable for adults?World journal of gastroenterology · 2021Review
- May Antitransglutaminase Levels Predict Severity of Duodenal Lesions in Adults with Celiac Disease?Medicina (Kaunas, Lithuania) · 2021Article
- Seronegative Celiac Disease; Frequently Encountered Yet Undiagnosed Clinical Entity.Middle East journal of digestive diseases · 2021Article
- Dysphagia as a Presentation of Celiac Disease.ACG case reports journal · 2020Article
- Predictivity of Autoimmune Stigmata for Gluten Sensitivity in Subjects with Microscopic Enteritis: A Retrospective Study.Nutrients · 2018Article
- Biological markers for non-celiac gluten sensitivity: a question awaiting for a convincing answer.Gastroenterology and hepatology from bed to bench · 2018Review
- Clinicopathological Study of Seronegative Celiac Disease in Adults in Pakistan: A Pilot Study.Middle East journal of digestive diseases · 2017Article
- Role of capsule endoscopy in suspected celiac disease: A European multi-centre study.World journal of gastroenterology · 2017Observational
- Clinical and genetic profile of patients with seronegative coeliac disease: the natural history and response to gluten-free diet.BMJ open gastroenterology · 2017Article
- Lymphocytic duodenitis or microscopic enteritis and gluten-related conditions: what needs to be explored?Annals of gastroenterology · 2017Review
- Seronegative Coeliac Disease in Children: A Case Report and Review of the Literature.Case reports in pediatrics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diagnosis of Celiac Disease (CD) relies on the concordance of pathological, serological, genetic and clinical features. For this reason, the diagnosis of CD is often a challenge. Seronegative celiac disease (SNCD) is defined by the negativity of anti-tissue transglutaminase antibodies in the presence of a positive histology on duodenal biopsy samples, i.e. inflammatory infiltrate of intra-epithelial lymphocytes (IELs > 25/100 enterocytes), mild villous atrophy and uneven brush border associated to human leukocyte antigen (HLA) haplotype DQ2 and/or DQ8. SNCD is characterized by mucosal deposits of tissue transglutaminase (tTG)/anti-tTG immuno-complexes. These may counteract the passage of anti-tTG into the bloodstream, thus explaining seronegativity. Another reason for seronegativity may be found in an incomplete maturation of plasma cells with a consequent failure of antibodies production. This condition often characterizes immunoglobulin deficiencies, and, indeed, SNCD is common in subjects with immunoglobulin deficiencies. The management of SNCD still remains debated. The treatment option for SNCD may be represented by gluten free diet (GFD), but the usefulness and appropriateness of prescribing GFD are controversial. Some evidences support its use only in SNCD subjects showing CD clear clinical picture and compatible HLA status. The choice of GFD administration could be linked to an investigation able to diagnose SNCD in no doubt even if a reliable test is not currently available. On these bases, a test helping the diagnosis of SNCD is justifiable and desirable.
Indexed as
Identifiers
25926935PMC4403023W1506114106What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.