Evidence map›Paper›PMID 25926889›Full record

ReviewPatient safety in surgery2015

Vitamin D status and surgical outcomes: a systematic review.

Paul J Iglar, Kirk J Hogan

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Patient safety in surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 40 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 4 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04229368 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Effect of Vitamin D Status and Repletion on Postoperative Total Joint Arthroplasty Complications

TypeinterventionalSponsorBrigham and Women's HospitalRan2019 to 2024Enrolled900ConditionsHip Arthropathy, Knee Arthropathy, Vitamin D DeficiencyArmsVitamin D3
NCT05522179 nacompletednot on this mapstarted 2022, after this paper: background citation

Nutritional Supplements to Support Recovery After Foot Surgery - A Pilot Study

TypeinterventionalSponsorNutraHealRan2022 to 2023Enrolled46ConditionsFoot Injuries and DisordersArmsNutraHeal, NutraHeal Plus
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 77 citations in OpenAlex.

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  9. Role of Micronutrients in Perioperative Care: A Systematic Review.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026
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  10. A comparative study of the injury patterns and inflammatory response between suicidal and unintentional falls from height in Germany.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Paul J IglarDepartment of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, 707 WARF Building, 610 North Walnut Street, Madison, WI 53726 USA.
Kirk J HoganDepartment of Anesthesiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, B/6 319 Clinical Sciences Center, Madison, WI 53792-3272 USA.
University of Wisconsin Health · USUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The importance of vitamin D for musculoskeletal health has long been recognized, and awareness of significant extra-skeletal effects in health and disease is rapidly emerging. Although it has been possible for many decades to quantify serum markers of vitamin D deficiency, and to correct deficiency at low cost and with high safety, the influence of vitamin D status on post-surgical outcomes has only recently been identified as a research topic of interest. To the present, these data have not been the subject matter of formal review. Accordingly, we conducted a systematic review to assess the association between perioperative vitamin D status and outcomes after surgery. The databases of PubMed, Ovid MEDLINE, EMBASE, AMED, CINAHL (EBSCOHost), The Cochrane Databases of Systematic Review, and PROSPERO were searched through December, 2014 for studies relating to vitamin D and surgery. The initial search yielded 90 manuscripts. After applying exclusion criteria, 31 studies were eligible for inclusion. Fifteen studies employed prospective observational designs, 3 used prospective randomized protocols, and 13 report retrospective database interrogations. The main finding of the present review is that 26 of 31 studies (84%) report at least one statistically significant worse outcome in patients with low vitamin D status. Five of 31 studies (16%) found no association. In conclusion, this review supports the hypothesis that hypovitaminosis D is associated with adverse outcomes after diverse surgical procedures. Future studies should focus on additional surgeries and outcomes, and on the role of vitamin D supplementation in the improvement of patient safety in participants with low vitamin D status at the time of surgery.

Indexed as

1,25-dihydroxyvitamin D3 (calcitriol)1,25-dihydroxyvitamin D3 (calcitriol) level25(OH)D (calcifediol)25(OH)D (calcifediol) levelPostoperative complicationPostoperative outcomeSurgery complicationSurgery outcomeVitamin D

Identifiers

PMID25926889
PMCPMC4413543
OpenAlexW2133770534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.