ArticleFrontiers in aging neuroscience2015
Theta and alpha EEG frequency interplay in subjects with mild cognitive impairment: evidence from EEG, MRI, and SPECT brain modifications.
Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed.
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- A Precision Computational Framework for sLORETA Neurofeedback in Mild Cognitive Impairment: Integration of qEEG Biomarkers and Neuropsychological Metrics.International journal of environmental research and public health · 2026Article
- Binaural Beat Stimulation Enhances Cognitive Function in Alzheimer's Disease via Temporal Lobe Activation: An sLORETA Study.Biomedicines · 2026Article
- Derivation of an intrinsic brain activity biomarker for the earliest prediction of cognitive decline.Scientific reports · 2026Article
- Integrating memory-guided saccades and EEG for MCI screening: a multimodal LASSO modeling approach.Frontiers in aging neuroscience · 2026Article
- EEG-based detection of early functional brain changes in subjective cognitive decline: a prospective cohort study.Alzheimer's research & therapy · 2025Article
- Preliminary study of sex-based neural responses and cognitive benefits of a 40 Hz rhythmic light intervention in mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2025Article
- Task-Related EEG as a Biomarker for Preclinical Alzheimer's Disease: An Explainable Deep Learning Approach.Biomimetics (Basel, Switzerland) · 2025Article
- Long-Term Changes in Brain Connectivity Reflected in Quantitative Electrophysiology of Symptomatic Former National Football League Players.Journal of neurotrauma · 2023Article
- The focused quantitative EEG bio-marker in studying childhood atrophic encephalopathy.Scientific reports · 2022Article
- Alpha3/alpha2 power ratios relate to performance on a virtual reality shopping task in ageing adults.Frontiers in aging neuroscience · 2022Article
- An objective model for diagnosing comorbid cognitive impairment in patients with epilepsy based on the clinical-EEG functional connectivity features.Frontiers in neuroscience · 2022Article
- Dysfunction of Emotion Regulation in Mild Cognitive Impairment Individuals Combined With Depressive Disorder: A Neural Mechanism Study.Frontiers in aging neuroscience · 2022Article
- A Graph Gaussian Embedding Method for Predicting Alzheimer's Disease Progression With MEG Brain Networks.IEEE transactions on bio-medical engineering · 2021Article
- A Comparison of Traditional and Serious Game-Based Digital Markers of Cognition in Older Adults with Mild Cognitive Impairment and Healthy Controls.Journal of Alzheimer's disease : JAD · 2021Article
- Higher hypnotic suggestibility is associated with the lower EEG signal variability in theta, alpha, and beta frequency bands.PloS one · 2020Article
- Associations between quantitative sleep EEG and subsequent cognitive decline in older women.Journal of sleep research · 2019Article
- Article
- Aberrant MEG multi-frequency phase temporal synchronization predicts conversion from mild cognitive impairment-to-Alzheimer's disease.NeuroImage. Clinical · 2019Article
- Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region.iScience · 2018Article
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Abstract
backgroundTemporo-parietal and medial temporal cortex atrophy are associated with mild cognitive impairment (MCI) due to Alzheimer disease (AD) as well as the reduction of regional cerebral blood perfusion in hippocampus. Moreover, the increase of EEG alpha3/alpha2 power ratio has been associated with MCI due to AD and with an increase in theta frequency power in a group of subjects with impaired cerebral perfusion in hippocampus.
methodsSeventy four adult subjects with MCI underwent clinical and neuropsychological evaluation, electroencephalogram (EEG) recording and high resolution 3D magnetic resonance imaging (MRI). Among the patients, a subset of 27 subjects underwent also perfusion single-photon emission computed tomography and hippocampal atrophy evaluation. Alpha3/alpha2 power ratio as well as cortical thickness was computed for each subject. Three MCI groups were detected according to increasing tertile values of alpha3/alpha2 power ratio and difference of cortical thickness among the groups estimated.
resultsHigher alpha3/alpha2 power ratio group had wider cortical thinning than other groups, mapped to the Supramarginal and Precuneus bilaterally. Subjects with higher alpha3/alpha2 frequency power ratio showed a constant trend to a lower perfusion than lower alpha3/alpha2 group. Moreover, this group correlates with both a bigger hippocampal atrophy and an increase of theta frequency power.
conclusionHigher EEG alpha3/alpha2 power ratio was associated with temporo-parietal cortical thinning, hippocampal atrophy and reduction of regional cerebral perfusion in medial temporal cortex. In this group an increase of theta frequency power was detected inMCI subjects. The combination of higher EEG alpha3/alpha2 power ratio, cortical thickness measure and regional cerebral perfusion reveals a complex interplay between EEG cerebral rhythms, structural and functional brain modifications.
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