ArticleReproduction (Cambridge, England)2015
Identification of target genes for a prolactin family paralog in mouse decidua.
Article in Reproduction (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Extracellular vesicle signatures from eye lavage as novel non-invasive biomarkers for hypoxic ischaemic insult-findings from a neonatal mouse model.Frontiers in medical technology · 2025Article
- Gene Regulatory Network Analysis of Decidual Stromal Cells and Natural Killer Cells.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Establishment of Murine Pregnancy Requires the Promyelocytic Leukemia Zinc Finger Transcription Factor.International journal of molecular sciences · 2024Article
- Uterine-specificiScience · 2023Article
- hnRNPL expression dynamics in the embryo and placenta.Gene expression patterns : GEP · 2023Article
- Notch effector recombination signal binding protein for immunoglobulin kappa J signaling is required for the initiation of endometrial stromal cell decidualization†.Biology of reproduction · 2022Article
- Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus.BMC biology · 2022Article
- Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling.Nature communications · 2022Article
- Single-cell analysis of mouse uterus at the invasion phase of embryo implantation.Cell & bioscience · 2022Article
- The Influence of the Prolactins on the Development of the Uterus in Neonatal Mice.Frontiers in veterinary science · 2022Article
- Identification of Intercellular Crosstalk between Decidual Cells and Niche Cells in Mice.International journal of molecular sciences · 2021Article
- Sexually dimorphic effects of forkhead box a2 (FOXA2) and uterine glands on decidualization and fetoplacental development.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Integrative analysis of transcriptomic data related to the liver of laying hens: from physiological basics to newly identified functions.BMC genomics · 2019Article
- Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy.PLoS biology · 2019Article
- PATL2 is a key actor of oocyte maturation whose invalidation causes infertility in women and mice.EMBO molecular medicine · 2018Article
- Hypoxia and Placental Development.Birth defects research · 2017Review
- The regulation of ovary and conceptus on the uterine natural killer cells during early pregnancy.Reproductive biology and endocrinology : RB&E · 2017Review
- Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood.Scientific reports · 2017Article
- Sustained Endocannabinoid Signaling Compromises Decidual Function and Promotes Inflammation-induced Preterm Birth.The Journal of biological chemistry · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Prolactin family 8, subfamily a, member 2 (PRL8A2; also called decidual prolactin-related protein; dPRP) is a member of the expanded prolactin family. PRL8A2 is expressed in the uterine decidua and contributes to pregnancy-dependent adaptations to hypoxia. The purpose of this study was to identify gene targets for PRL8A2 action within the uteroplacental compartment. Affymetrix DNA microarray analysis was performed for RNA samples from WT and Prl8a2 null tissues. Validation of the DNA microarray was performed using quantitative RT-PCR. Nine genes were confirmed with decreased expression in Prl8a2 null tissues (e.g., Klk7, Rimklb, Arhgef6, Calm4, Sprr2h, Prl4a1, Ccl27, Lipg, and Htra3). These include potential decidual, endothelial and trophoblast cell targets positively regulated by PRL8A2. A significant upregulation of Derl3, Herpud1, Creld2, Hsp90b1, Ddit3 and Hspa5 was identified in Prl8a2 null tissues, reflecting an increased endoplasmic reticulum (ER) stress response. ER stress genes were prominently expressed in the uterine decidua. We propose that PRL8A2 is a mediator of progesterone-dependent modulation of intrauterine responses to physiological stressors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.