Evidence map›Paper›PMID 25926639›Full record

ArticleJournal of virology2015

Newcastle Disease Virus-Vectored H7 and H5 Live Vaccines Protect Chickens from Challenge with H7N9 or H5N1 Avian Influenza Viruses.

Qinfang Liu, Ignacio Mena, Jingjiao Ma, Bhupinder Bawa, Florian Krammer, Young S Lyoo, Yuekun Lang, Igor Morozov, Gusti Ngurah Mahardika, Wenjun Ma and 2 more

Abstract read
In one paragraph

Article in Journal of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Viral vector-based influenza vaccines.Human vaccines & immunotherapeutics · 2016
    Pooled it
  2. Review
  3. Negative-Strand RNA Virus-Vectored Vaccines.Methods in molecular biology (Clifton, N.J.) · 2024
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. A Decade of Avian Influenza in Bangladesh: Where Are We Now?Tropical medicine and infectious disease · 2019
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qinfang LiuDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, Kansas, USA.
Ignacio MenaDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jingjiao MaDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, Kansas, USA.
Bhupinder BawaDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, Kansas, USA.
Florian KrammerDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Young S LyooDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, Kansas, USA.
Yuekun LangDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, Kansas, USA.
Igor MorozovDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, Kansas, USA.
Gusti Ngurah MahardikaUniversity of Udayana, Denpasar, Bali, Indonesia.
Wenjun MaDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, Kansas, USA.
Adolfo García-SastreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA Adolfo.Garcia-Sastre@mssm.edu jricht@vet.k-state.edu.
Juergen A RichtDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, Kansas, USA Adolfo.Garcia-Sastre@mssm.edu jricht@vet.k-state.edu.

Funding

STRUCTURAL STUDIES IN THE CENTRAL NERVOUS SYSTEMP01AG000001 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENE, DOUGLAS L · 1985 to 2013
$20.7M
NIAID NIH HHS HHSN266200700005CNIA NIH HHS P01 AG000001PHS HHS HHSN266200700005C
6 · The paper itself

Abstract

Sporadic human infections by a novel H7N9 virus occurred over a large geographic region in China. In this study, we show that Newcastle disease virus (NDV)-vectored H7 (NDV-H7) and NDV-H5 vaccines are able to induce antibodies with high hemagglutination inhibition (HI) titers and completely protect chickens from challenge with the novel H7N9 or highly pathogenic H5N1 viruses, respectively. Notably, a baculovirus-expressed H7 protein failed to protect chickens from H7N9 virus infection.

Indexed as

AnimalsAntibodies, ViralChickensChinaDrug CarriersHemagglutination Inhibition TestsHemagglutinin Glycoproteins, Influenza VirusInfluenza A Virus, H5N1 SubtypeInfluenza A Virus, H7N9 SubtypeInfluenza in BirdsInfluenza VaccinesNewcastle disease virusSurvival AnalysisVaccines, AttenuatedAntibodies, ViralDrug Carriershemagglutinin, avian influenza A virusHemagglutinin Glycoproteins, Influenza VirusInfluenza VaccinesVaccines, Attenuated

Identifiers

PMID25926639
PMCPMC4473557

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.