ReviewAsian journal of andrology
New insights into the regulation of cholesterol efflux from the sperm membrane.
Review in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Networks Models of Actin Dynamics during Spermatozoa Postejaculatory Life: A Comparison among Human-Made and Text Mining-Based Models.BioMed research international · 2016Pooled it
- Impact of Sorting and Catch Media on Porcine Sperm Motility, Capacitation, and Viability.Andrology · 2026Article
- Niemann-Pick type C2-mediated cholesterol sequestration induces capacitation-like sperm remodeling during reproductive tract transit in the blue swimming crab (Portunus pelagicus).Veterinary world · 2026Article
- Interplay Between Sperm Function and Seminal Plasma Biochemical Profile in a Group of Normozoospermic Subjects.Biomolecules · 2026Article
- The maternal immune response to semen: implications for reproductive success in livestock.Reproduction & fertility · 2026Review
- Age-Associated Metabolomic Changes in Human Spermatozoa.International journal of molecular sciences · 2026Article
- Functional and Molecular Characterization of Melamine-Induced Disruption of Human Spermatozoa via Oxidative Stress and Apoptotic Pathways: An In Vitro Study.Antioxidants (Basel, Switzerland) · 2026Article
- Zinc regulation of lipidome remodeling during boar sperm capacitation.Journal of animal science · 2026Article
- Sperm capacitation in bulls, rams, bucks, and boars: molecular mechanisms and species-specific differences.Frontiers in veterinary science · 2026Review
- A special perspective on human fertilization: The role of sperm capacitation proteins and channels: A narrative review.International journal of reproductive biomedicine · 2025Review
- Novel insights into the lipid signalling in human spermatozoa.Human reproduction (Oxford, England) · 2025Review
- Sperm Membrane: Molecular Implications and Strategies for Cryopreservation in Productive Species.Animals : an open access journal from MDPI · 2025Review
- Effects of Cholesterol on the Breast Cancer Resistance Protein: Studies through the Synthesis and Biological Evaluation of Chemical Tools.ChemMedChem · 2025Article
- Mechanisms of oxidative stress-induced sperm dysfunction.Frontiers in endocrinology · 2025Review
- Metabolic Shift in Porcine Spermatozoa during Sperm Capacitation-Induced Zinc Flux.International journal of molecular sciences · 2024Article
- Lipid remodeling in acrosome exocytosis: unraveling key players in the human sperm.Frontiers in cell and developmental biology · 2024Review
- Catechin versus MoSInternational journal of molecular sciences · 2023Article
- Cholesterol inhibits human voltage-gated proton channel hHv1.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A Review on the Role of Bicarbonate and Proton Transporters during Sperm Capacitation in Mammals.International journal of molecular sciences · 2022Review
- Sperm Lipid Markers of Male Fertility in Mammals.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cholesterol is an essential component of the mammalian plasma membrane because it promotes membrane stability without comprising membrane fluidity. Given this important cellular role, cholesterol levels are tightly controlled at multiple levels. It has been clearly shown that cholesterol redistribution and depletion from the sperm membrane is a key part of the spermatozoon's preparation for fertilization. Some factors that regulate these events are described (e.g., bicarbonate, calcium) but the mechanisms underlying cholesterol export are poorly understood. How does a hydrophobic cholesterol molecule inserted in the sperm plasma membrane enter the energetically unfavorable aqueous surroundings? This review will provide an overview of knowledge in this area and highlight our gaps in understanding. The overall aim is to better understand cholesterol redistribution in the sperm plasma membrane, its relation to the possible activation of a cholesterol transporter and the role of cholesterol acceptors. Armed with such knowledge, sperm handling techniques can be adapted to better prepare spermatozoa for in vitro and in vivo fertilization.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.