ArticleAsian journal of andrology
Role of C-type natriuretic peptide in the function of normal human sperm.
Article in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Efficiency of C-type natriuretic peptide on improvement of Iraqi local ram's epididymal sperms.Open veterinary journal · 2024Article
- Effect of C-Type Natriuretic Peptide (CNP) on Spermatozoa Maturation in Adult Rat Epididymis.Current issues in molecular biology · 2023Article
- The Mature COC Promotes the Ampullary NPPC Required for Sperm Release from Porcine Oviduct Cells.International journal of molecular sciences · 2023Article
- The oocyte cumulus complex regulates mouse sperm migration in the oviduct.Communications biology · 2022Article
- C-Type Natriuretic Peptide (CNP) Could Improve Sperm Motility and Reproductive Function of Asthenozoospermia.International journal of molecular sciences · 2022Article
- Cryopreservation process alters the expression of genes involved in pathways associated with the fertility of bull spermatozoa.Frontiers in genetics · 2022Article
- Seasonal differences in seminal plasma proteins from two bovine breeds adapted to a subtropical climate.Tropical animal health and production · 2021Article
- Sperm Functional Genome Associated With Bull Fertility.Frontiers in veterinary science · 2021Review
- C-Type Natriuretic Peptide Plays an Anti-Inflammatory Role in Rat Epididymitis Induced byFrontiers in cellular and infection microbiology · 2021Article
- Discovery of a receptor guanylate cyclase expressed in the sperm flagella of stony corals.Scientific reports · 2019Article
- C-Type Natriuretic Peptide/Natriuretic Peptide Receptor 2 Is Involved in Cell Proliferation and Testosterone Production in Mouse Leydig Cells.The world journal of men's health · 2019Article
- Proteomic landscape of seminal plasma associated with dairy bull fertility.Scientific reports · 2018Article
- Microglial activation: an important process in the onset of epilepsy.American journal of translational research · 2018Article
- Natriuretic peptide type C induces sperm attraction for fertilization in mouse.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C-type natriuretic peptide (CNP) is a newly discovered type of local regulatory factor that mediates its biological effects through the specific, membrane-bound natriuretic peptide receptor-B (NPR-B). Recent studies have established that CNP is closely related to male reproductive function. The aims of this study were to determine the distribution of CNP/NPR-B in human ejaculated spermatozoa through different methods (such as immunolocalization, real time polymerase chain reaction and Western Blot), and then to evaluate the influence of CNP on sperm function i n vitro, such as motility and acrosome reaction. Human semen samples were collected from consenting donors who met the criteria of the World Health Organization for normozoospermia. Our results show that the specific receptor NPR-B of CNP is localized in the acrosomal region of the head and the membrane of the front-end tail of the sperm, and there is no signal of CNP in human sperm. Compared with the control, CNP can induce a significant dose-dependent increase in spermatozoa motility and acrosome reaction. In summary, CNP/NPR-B can affect sperm motility and acrosome reaction, thus regulating the reproductive function of males. CNP may be a new key factor in regulating sperm function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.