ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Neuropeptide receptor transcript expression levels and magnitude of ionic current responses show cell type-specific differences in a small motor circuit.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
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- Modulation by Neuropeptides with Overlapping Targets Results in Functional Overlap in Oscillatory Circuit Activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Localization of chemical synapses and modulatory release sites in the cardiac ganglion of the crab, Cancer borealis.The Journal of comparative neurology · 2022Article
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- Mass spectrometry profiling and quantitation of changes in circulating hormones secreted over time in Cancer borealis hemolymph due to feeding behavior.Analytical and bioanalytical chemistry · 2022Article
- Feeding state-dependent modulation of feeding-related motor patterns.Journal of neurophysiology · 2021Article
- Perturbation-specific responses by two neural circuits generating similar activity patterns.Current biology : CB · 2021Article
- Neuropeptide Modulation Increases Dendritic Electrical Spread to Restore Neuronal Activity Disrupted by Temperature.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Does Differential Receptor Distribution Underlie Variable Responses to a Neuropeptide in the Lobster Cardiac System?International journal of molecular sciences · 2021Article
- Neuropeptide ACP facilitates lipid oxidation and utilization during long-term flight in locusts.eLife · 2021Article
- Hormone-like conopeptides - new tools for pharmaceutical design.RSC medicinal chemistry · 2020Review
- Differential neuropeptide modulation of premotor and motor neurons in the lobster cardiac ganglion.Journal of neurophysiology · 2020Article
- To what extent may peptide receptor gene diversity/complement contribute to functional flexibility in a simple pattern-generating neural network?Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2019Article
- Innexin expression in electrically coupled motor circuits.Neuroscience letters · 2019Review
- Graded Transmission without Action Potentials Sustains Rhythmic Activity in Some But Not All Modulators That Activate the Same Current.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Distinct Co-Modulation Rules of Synapses and Voltage-Gated Currents Coordinate Interactions of Multiple Neuromodulators.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- General Principles of Neuronal Co-transmission: Insights From Multiple Model Systems.Frontiers in neural circuits · 2018Review
- Article
- State-dependent sensorimotor gating in a rhythmic motor system.Journal of neurophysiology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
We studied the relationship between neuropeptide receptor transcript expression and current responses in the stomatogastric ganglion (STG) of the crab, Cancer borealis. We identified a transcript with high sequence similarity to crustacean cardioactive peptide (CCAP) receptors in insects and mammalian neuropeptide S receptors. This transcript was expressed throughout the nervous system, consistent with the role of CCAP in a range of different behaviors. In the STG, single-cell qPCR showed expression in only a subset of neurons. This subset had previously been shown to respond to CCAP with the activation of a modulator-activated inward current (IMI), with one exception. In the one cell type that showed expression but no IMI responses, we found CCAP modulation of synaptic currents. Expression levels within STG neuron types were fairly variable, but significantly different between some neuron types. We tested the magnitude and concentration dependence of IMI responses to CCAP application in two identified neurons, the lateral pyloric (LP) and the inferior cardiac (IC) neurons. LP had several-fold higher expression and showed larger current responses. It also was more sensitive to low CCAP concentrations and showed saturation at lower concentrations, as sigmoid fits showed smaller EC50 values and steeper slopes. In addition, occlusion experiments with proctolin, a different neuropeptide converging onto IMI, showed that saturating concentrations of CCAP activated all available IMI in LP, but only approximately two-thirds in IC, the neuron with lower receptor transcript expression. The implications of these findings for comodulation are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.