ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Anti-Ganglioside Antibodies Induce Nodal and Axonal Injury via Fcγ Receptor-Mediated Inflammation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Trial
- Genetic variation of low-to-medium-affinity Fc-gamma receptors in Guillain-Barré syndrome.Journal of neurology · 2025Article
- Canine leishmaniosis and peripheral neuropathy: a lesson from the neurologist.Parasites & vectors · 2025Article
- Analysis of 977 Long COVID Patients Reveals Prevalent Neuropathy and Association with Anti-Ganglioside Antibodies.medRxiv : the preprint server for health sciences · 2025Article
- Predictors of the Short-Term Outcomes of Guillain-Barré Syndrome: Exploring Electrodiagnostic and Clinical Features.Brain and behavior · 2025Article
- Endoneurial immune interplay in peripheral nerve repair: insights and implications for future therapeutic interventions.Frontiers in neuroscience · 2025Review
- Polyneuropathy in systemic sclerosis: exploring the causes and biomarkers.Frontiers in medicine · 2024Article
- Skin Biopsy as a Novel Diagnostic Aid in Immune-Mediated Neuropathies.Journal of neuropathology and experimental neurology · 2022Article
- Therapeutic Monoclonal Antibody Therapies in Chronic Autoimmune Demyelinating Neuropathies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Axonal variants of Guillain-Barré syndrome: an update.Journal of neurology · 2021Review
- FcεR1-expressing nociceptors trigger allergic airway inflammation.The Journal of allergy and clinical immunology · 2021Article
- Case Report: Plasma Biomarkers Reflect Immune Mechanisms of Guillain-Barré Syndrome.Frontiers in neurology · 2021Article
- Elimination of activating Fcγ receptors in spontaneous autoimmune peripheral polyneuropathy model protects from neuropathic disease.PloS one · 2019Article
- Immune-mediated neuropathies.Nature reviews. Disease primers · 2018Review
- Systemic IGF-1 gene delivery by rAAV9 improves spontaneous autoimmune peripheral polyneuropathy (SAPP).Scientific reports · 2018Article
- Engineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactions.Communications biology · 2018Article
- Serum Antibodies to Glycans in Peripheral Neuropathies.Molecular neurobiology · 2017Review
- Role of Fcγ Receptor Mediated Inflammation in Immune Neuropathies.Journal of clinical & cellular immunology · 2017Article
- Dissecting the Role of Anti-ganglioside Antibodies in Guillain-Barré Syndrome: an Animal Model Approach.Molecular neurobiology · 2016Review
- Sialylated intravenous immunoglobulin suppress anti-ganglioside antibody mediated nerve injury.Experimental neurology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Guillain-Barré syndrome (GBS) is a postinfectious autoimmune neuropathy and anti-ganglioside antibodies (Abs) are strongly associated with this disorder. Several studies have implied that specific anti-ganglioside Abs induce neuropathy in patients with axonal forms of GBS. To study the mechanisms of anti-ganglioside Abs-induced neuropathy, we established a new passive transfer mouse model by L5 spinal nerve transection (L5SNT; modified Chung's model) and systemic administration of anti-ganglioside Abs. L5SNT causes degeneration of a small proportion of fibers that constitute sciatic nerve and its branches, but importantly breaks the blood-nerve barrier, which allows access to circulating Abs and inflammatory cells. Our studies indicate that, in this mouse model, anti-ganglioside Abs induce sequential nodal and axonal injury of intact myelinated nerve fibers, recapitulating pathologic features of human disease. Notably, our results showed that immune complex formation and the activating Fc gamma receptors (FcγRs) were involved in the anti-ganglioside Abs-mediated nodal and axonal injury in this model. These studies provide new evidence that the activating FcγRs-mediated inflammation plays a critical role in anti-ganglioside Abs-induced neuropathy (injury to intact nerve fibers) in GBS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.