Evidence map›Paper›PMID 25926400›Full record

ArticleComparative medicine2015

Comparative Immunohistochemistry of Placental Corticotropin-Releasing Hormone and the Transcription Factor RelB-NFκB2 Between Humans and Nonhuman Primates.

Todd Rosen, Jay Schulkin, Michael Power, Serkalem Tadesse, Errol R Norwitz, Zhaoqin Wen, Bingbing Wang

Open access · greenAbstract readComparative Study
PubMed Full text at PMC
In one paragraph

Article in Comparative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Todd RosenDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA. rosentj@rwjms.rutgers.edu.
Jay SchulkinResearch Department, American College of Obstetricians and Gynecologists, Washington, District of Columbia, USA; Department of Neuroscience, Georgetown University, Washington, District of Columbia, USA.
Michael PowerNutrition Laboratory, Conservation Ecology Center, Smithsonian Conservation Biology Institute, National Zoological Park, Washington, District of Columbia, USA.
Serkalem TadesseTufts University School of Medicine, Department of Obstetrics and Gynecology, Boston, Massachusetts, USA.
Errol R NorwitzTufts University School of Medicine, Department of Obstetrics and Gynecology, Boston, Massachusetts, USA.
Zhaoqin WenDepartment of Pathology, Saint Peter's University Hospital, New Brunswick, New Jersey, USA.
Bingbing WangDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA. wangbi@rwjms.rutgers.edu.
Rutgers, The State University of New Jersey · USTufts University · USSmithsonian Conservation Biology Institute · US

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
NIH HHS P51 OD011133
6 · The paper itself

Abstract

The transcription factor RelB-NFκB2, activated by the noncanonical NFκB pathway, positively regulates corticotropin-releasing hormone (CRH) and prostaglandin production in the term human placenta and may play an important role in the timing of human parturition. Here we explored whether RelB-NFκB2 signaling plays a role in parturition in nonhuman anthropoid primates. We performed immunohistochemical staining to assess the correlation between CRH and nuclear activity of RelB-NFκB2 heterodimers in term placentas from humans, 3 catarrhine primate species, and a single platyrrhine primate species. Consistent with our previous studies, the human placenta showed cytoplasmic staining for CRH and nuclear staining for RelB-NFκB2. Similar staining patterns were noted in the 3 catarrhine primates (chimpanzee, baboon, and rhesus macaque). The platyrrhine (marmoset) placentas stained positively for CRH and RelB but not for NFκB2. Catarrhine (but not platyrrhine) nonhuman primate term placentas demonstrate the same CRH staining and nuclear localization patterns of RelB and NFκB2 as does human placenta. These results suggest that catarrhine primates, particularly rhesus macaques, may serve as useful animal models to study the biologic significance of the noncanonical NFκB pathway in human pregnancy.

Indexed as

AnimalsCallithrixCorticotropin-Releasing HormoneFemaleHumansImmunohistochemistryMacaca mulattaModels, AnimalNF-kappa B p52 SubunitPan troglodytesPapio hamadryasPlacentaPlacental HormonesPregnancyPrimatesSignal TransductionCorticotropin-Releasing HormoneNF-kappa B p52 SubunitPlacental HormonesTranscription Factor RelB

Identifiers

PMID25926400
PMCPMC4408900
OpenAlexW2431172914

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.