Evidence map›Paper›PMID 25926395›Full record

ReviewComparative medicine2015

Practical murine hematopathology: a comparative review and implications for research.

Karyn E O'Connell, Amy M Mikkola, Aaron M Stepanek, Andyna Vernet, Christopher D Hall, Chia C Sun, Eda Yildirim, John F Staropoli, Jeannie T Lee, Diane E Brown

Abstract readComparative StudyReview
In one paragraph

Review in Comparative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

163 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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103 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Karyn E O'ConnellDepartment of Comparative Pathology, New England Primate Research Center, Harvard Medical School, Southboro, Massachusetts, USA.
Amy M MikkolaCenter for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Aaron M StepanekCenter for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Public Health and Professional Degree Program, Tufts University School of Medicine, Boston, Massachusetts, USA.
Andyna VernetCenter for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, Massachusetts, USA.
Christopher D HallCenter for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Chia C SunProgram in Anemia Signaling Research, Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts, USA; Program in Membrane Biology, Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, Cellular and Translational Immunology, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.
Eda YildirimDepartment of Molecular Biology, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA.
John F StaropoliMolecular Neurogenetics Unit, Center for Human Genetic Research, Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA; Biogen Idec, Cambridge, Massachusetts, USA.
Jeannie T LeeDepartment of Molecular Biology, Center for Human Genetic Research, Department of Pathology, Harvard Medical School, Howard Hughes Medical Institute, Harvard Medical School, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Diane E BrownCenter for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA. dbrown31@mgh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hematologic parameters are important markers of disease in human and veterinary medicine. Biomedical research has benefited from mouse models that recapitulate such disease, thus expanding knowledge of pathogenetic mechanisms and investigative therapies that translate across species. Mice in health have many notable hematologic differences from humans and other veterinary species, including smaller erythrocytes, higher percentage of circulating reticulocytes or polychromasia, lower peripheral blood neutrophil and higher peripheral blood and bone marrow lymphocyte percentages, variable leukocyte morphologies, physiologic splenic hematopoiesis and iron storage, and more numerous and shorter-lived erythrocytes and platelets. For accurate and complete hematologic analyses of disease and response to investigative therapeutic interventions, these differences and the unique features of murine hematopathology must be understood. Here we review murine hematology and hematopathology for practical application to translational investigation.

Indexed as

HematologyPathology, VeterinaryAnimalsBone MarrowDisease Models, AnimalHematologic DiseasesHematopoiesisHumansMiceTranslational Research, Biomedical

Identifiers

PMID25926395
PMCPMC4408895

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.