SynthesisUrolithiasis2015
The efficacy and safety of percutaneous nephrolithotomy under general versus regional anesthesia: a systematic review and meta-analysis.
Synthesis in Urolithiasis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Comparison of regional and general anesthesia for retrograde intrarenal surgery: a systematic review and meta-analysis.Frontiers in surgery · 2025Pooled it
- GeneralF1000Research · 2023Pooled it
- Outcomes of Retrograde Intrarenal Surgery Performed Under Neuraxial vs. General Anesthesia: An Updated Systematic Review and Meta-Analysis.Frontiers in surgery · 2022Pooled it
- Ultrasound guided retrolaminar block reduces postoperative gastrointestinal system dysfunctions during percutaneous nephrolithotomy: a prospective, randomised, double-blind, clinical study.Scientific reports · 2025Trial
- Ultrasound-guided anterior quadratus lumborum block for postoperative pain after percutaneous nephrolithotomy: a randomized controlled trial.Korean journal of anesthesiology · 2020Trial
- Trial
- The Effect of Peritubal Infiltration with Bupivacaine and Morphine on Postoperative Analgesia in Patients Undergoing Percutaneous Nephrolithotomy.Pain research & management · 2017Trial
- Thoracic Paravertebral Block versus Epidural Anesthesia Combined with Moderate Sedation for Percutaneous Nephrolithotomy.Medical principles and practice : international journal of the Kuwait University, Health Science CentreTrial
- Towards 3D-dense ultrasound image simulation from 2D CT scans for ultrasound-guided percutaneous nephrolithotomy: a progressive training approach from basic to advanced simulator complexity.Medical & biological engineering & computing · 2026Article
- World-wide variation in percutaneous nephrolithotomy practices: evaluation based on training, experience, and region.World journal of urology · 2025Article
- Article
- Article
- Comparative analysis of combined spinal-epidural anesthesia and general anesthesia in percutaneous nephrolithotomy: a prospective study on surgical team and operating room personnel satisfaction.World journal of urology · 2024Article
- Regional versus general anaesthesia in percutaneous nephrolithotomy: a systematic review and meta-analysis.Central European journal of urology · 2024Review
- Article
- Comparison of paravertebral block vs. general anesthesia for percutaneous nephrolithotomy: A retrospective study.Frontiers in medicine · 2023Article
- Efficacy and safety of percutaneous nephrolithotomy combined with negative pressure suction in the treatment of renal calculi: a systematic review and meta-analysis.Translational andrology and urology · 2022Article
- Research progress of percutaneous nephrolithotomy.International urology and nephrology · 2018Review
- Is segmental epidural anaesthesia an optimal technique for patients undergoing percutaneous nephrolithotomy?Indian journal of anaesthesia · 2017Article
- Retrograde intrarenal surgery with central neuraxial blockade versus general anesthesia: A systematic review and meta-analysis.Saudi journal of anaesthesiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This meta-analysis was performed to evaluate the efficacy and safety of percutaneous nephrolithotomy (PCNL) under regional anesthesia (RA) vs. general anesthesia (GA). A systematic literature search in the electronic databases (Cochrane CENTRAL, Medline and EMBASE) was performed up to April 2014. Twelve trials, including 1954 patients, met the inclusion criteria and were included in the final analysis. Our pooled analysis showed that PCNL under RA could reduce surgical duration (MD, -2.47; 95 % CI, -3.51 to -1.44), hospitalization period (MD, -0.48; 95 % CI -0.93 to -0.04), fluoroscopy time (MD, -0.48; 95 % CI, -0.83 to -0.14), blood transfusion (OR, 0.59; 95 % CI, 0.38-0.92), postoperative pain (MD, -1.99; 95 % CI, -2.2 to -1.78), and analgesic requirements (MD, -19.14; 95 % CI, -26.64 to -11.63). However, there was no difference between RA and GA groups with regard to stone-free rate (OR, 1.09; 95 % CI, 0.86-1.37) and postoperative complications associated with PCNL (OR, 0.95; 95 % CI 0.58-1.54). Our results show that PCNL under RA offers several potential advantages over GA in terms of surgical duration, hospitalization period, fluoroscopy time, blood transfusion, postoperative pain, and analgesic requirements, but both anesthetic techniques appear to be equivalent with regard to the stone-free rate and complication rate. Along with the suggested favorable hemodynamic profile and lower cost, RA may prove a better alternative than GA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.