Evidence map›Paper›PMID 25926123›Full record

ArticleEnvironmental health : a global access science source2015

The association of long-term exposure to PM2.5 on all-cause mortality in the Nurses' Health Study and the impact of measurement-error correction.

Jaime E Hart, Xiaomei Liao, Biling Hong, Robin C Puett, Jeff D Yanosky, Helen Suh, Marianthi-Anna Kioumourtzoglou, Donna Spiegelman, Francine Laden

Abstract read
In one paragraph

Article in Environmental health : a global access science source, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The association between PMEnvironmental research · 2026
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  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
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  11. Growing Evidence for the Role of Air Pollution in Breast Cancer Development.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Article
  12. A comparison of PMEnvironmental research · 2024
    Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Geospatial Science for the Environmental Epidemiology of Cancer in the Exposome Era.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
    Article
  18. Comparison ofEnvironmental health perspectives · 2024
    Article
  19. Article
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jaime E HartChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 401 Park Drive, Landmark Center, Boston, MA, 02215, USA. Jaime.hart@channing.harvard.edu.
Xiaomei LiaoDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA. stxia@channing.harvard.edu.
Biling HongDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA. stbho@channing.harvard.edu.
Robin C PuettMaryland Institute for Applied Environmental Health, University of Maryland School of Public Health, 2234 School of Public Health, College Park, MD, 20742, USA. rpuett@umd.edu.
Jeff D YanoskyDepartment of Public Health Sciences, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA. JYanosky@phs.psu.edu.
Helen SuhDepartment of Health Sciences, Bouve College of Health Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, USA. h.suh@neu.edu.
Marianthi-Anna KioumourtzoglouDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, 401 Park Drive, Landmark Center, Boston, MA, 02215, USA. marianthi.anna@mail.harvard.edu.
Donna SpiegelmanDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA. stdls@hsph.harvard.edu.
Francine LadenChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 401 Park Drive, Landmark Center, Boston, MA, 02215, USA. Francine.laden@channing.harvard.edu.

Funding

Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Training Program in Environmental EpidemiologyT32ES007069 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LADEN, FRANCINE · 1985 to 2024
$13.9M
MARYLAND POPULATION RESEARCH CENTERR24HD041041 · NICHD · UNIV OF MARYLAND, COLLEGE PARK · PI HOFFERTH, SANDRA L · 2001 to 2016
$6.6M
MEASUREMENT ERRORS IN ENVIRONMENTAL EPIDEMIOLOGYR01ES009411 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SPIEGELMAN, DONNA L · 1999 to 2013
$2.9M
New Methods for the design and evaluation of large HIV prevention interventionsR01AI112339 · NIAID · YALE UNIVERSITY · PI SPIEGELMAN, DONNA L · 2014 to 2017
$2.7M
DIET, PHYSICAL ACTIVITY, AND THE RELATIONSHIP BETWEEN AIR POLLUTION AND CVDR01ES017017 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI LADEN, FRANCINE · 2009 to 2012
$1.7M
NCI NIH HHS UM1 CA186107NIAID NIH HHS R01 AI112339NICHD NIH HHS R24 HD041041NIEHS NIH HHS L30 ES016988NIEHS NIH HHS R01 ES009411NIEHS NIH HHS R01 ES017017NIEHS NIH HHS T32 ES007069
6 · The paper itself

Abstract

backgroundLong-term exposure to particulate matter less than 2.5 μm in diameter (PM2.5) has been consistently associated with risk of all-cause mortality. The methods used to assess exposure, such as area averages, nearest monitor values, land use regressions, and spatio-temporal models in these studies are subject to measurement error. However, to date, no study has attempted to incorporate adjustment for measurement error into a long-term study of the effects of air pollution on mortality.

methodsWe followed 108,767 members of the Nurses' Health Study (NHS) 2000-2006 and identified all deaths. Biennial mailed questionnaires provided a detailed residential address history and updated information on potential confounders. Time-varying average PM2.5 in the previous 12-months was assigned based on residential address and was predicted from either spatio-temporal prediction models or as concentrations measured at the nearest USEPA monitor. Information on the relationships of personal exposure to PM2.5 of ambient origin with spatio-temporal predicted and nearest monitor PM2.5 was available from five previous validation studies. Time-varying Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95 percent confidence intervals (95%CI) for each 10 μg/m(3) increase in PM2.5. Risk-set regression calibration was used to adjust estimates for measurement error.

resultsIncreasing exposure to PM2.5 was associated with an increased risk of mortality, and results were similar regardless of the method chosen for exposure assessment. Specifically, the multivariable adjusted HRs for each 10 μg/m(3) increase in 12-month average PM2.5 from spatio-temporal prediction models were 1.13 (95%CI:1.05, 1.22) and 1.12 (95%CI:1.05, 1.21) for concentrations at the nearest EPA monitoring location. Adjustment for measurement error increased the magnitude of the HRs 4-10% and led to wider CIs (HR = 1.18; 95%CI: 1.02, 1.36 for each 10 μg/m(3) increase in PM2.5 from the spatio-temporal models and HR = 1.22; 95%CI: 1.02, 1.45 from the nearest monitor estimates).

conclusionsThese findings support the large body of literature on the adverse effects of PM2.5, and suggest that adjustment for measurement error be considered in future studies where possible.

Indexed as

Environmental ExposureMortalityAdultAir PollutionEnvironmental MonitoringFemaleHumansIncidenceNursesParticle SizeParticulate MatterProspective StudiesUnited StatesParticulate Matter

Identifiers

PMID25926123
PMCPMC4427963

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.