ReviewNeurologia medico-chirurgica2015
New Approach for Exploring Cerebral Functional Connectivity: Review of Cortico-cortical Evoked Potential.
Review in Neurologia medico-chirurgica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07789938 (Intraoperative Monitoring of Motor, Visual and Cortico-cortical Evoked Potentials in Brain Tumor Surgery Under General Anesthesia), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intraoperative Monitoring of Motor, Visual and Cortico-cortical Evoked Potentials in Brain Tumor Surgery Under General Anesthesia: Prospective Cohort Studies
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuromonitoring of the language pathways using cortico-cortical evoked potentials: a systematic review and meta-analysis.Neurosurgical review · 2022Pooled it
- High-resolution electrophysiological mapping of effective connectivity of lateral prefrontal cortex.Brain : a journal of neurology · 2026Article
- Mapping human thalamocortical connectivity with electrical stimulation and recording.Nature neuroscience · 2025Article
- Intracranial EEG-Based Directed Functional Connectivity in Alpha to Gamma Frequency Range Reflects Local Circuits of the Human Mesiotemporal Network.Brain topography · 2024Article
- Causal Cortical and Thalamic Connections in the Human Brain.bioRxiv : the preprint server for biology · 2024Article
- Intracortical mechanisms of single pulse electrical stimulation (SPES) evoked excitations and inhibitions in humans.Scientific reports · 2024Article
- The Neurostimulationist will see you now: prescribing direct electrical stimulation therapies for the human brain in epilepsy and beyond.Frontiers in human neuroscience · 2024Review
- Evaluating cortical excitatory and inhibitory activity through interictal intracranial electroencephalography in mesial temporal lobe epilepsy.Frontiers in neuroscience · 2024Article
- Spectro-spatial features in distributed human intracranial activity proactively encode peripheral metabolic activity.Nature communications · 2023Article
- Physiological and pathological neuronal connectivity in the living human brain based on intracranial EEG signals: the current state of research.Frontiers in network physiology · 2023Review
- A review on surgical treatment options in gliomas.Frontiers in oncology · 2023Review
- Prediction of Postoperative Speech Dysfunctions in Neurosurgery Based on Cortico-Cortical Evoked Potentials and Machine Learning Technology.Sovremennye tekhnologii v meditsine · 2022Article
- Active probing to highlight approaching transitions to ictal states in coupled neural mass models.PLoS computational biology · 2021Article
- Quantification of Epileptogenic Network From Stereo EEG Recordings Using Epileptogenicity Ranking Method.Frontiers in neurology · 2021Article
- Probing regional cortical excitability via input-output properties using transcranial magnetic stimulation and electroencephalography coupling.Human brain mapping · 2020Article
- What Direct Electrostimulation of the Brain Taught Us About the Human Connectome: A Three-Level Model of Neural Disruption.Frontiers in human neuroscience · 2020Article
- Spatial and Temporal Heterogeneities of Capillary Hemodynamics and Its Functional Coupling During Neural Activation.IEEE transactions on medical imaging · 2019Article
- Inferring Cortical Connectivity from ECoG Signals Using Graph Signal Processing.IEEE access : practical innovations, open solutions · 2019Article
- Critical Language Areas Show Increased Functional Connectivity in Human Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Understanding the Hierarchical Organization of Large-Scale Networks Based on Temporal Modulations in Patterns of Neural Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been a paradigm shift in the understanding of brain function. The intrinsic architecture of neuronal connections forms a key component of the cortical organization in our brain. Many imaging studies, such as noninvasive magnetic resonance imaging (MRI) studies, have now enabled visualization of the white matter fiber tracts interconnecting the functional cortical areas in the living brain. Although such a structural connectome is essential for understanding of cortical function, the anatomical information alone is not sufficient. Practically, few techniques allow the investigation of the excitatory and inhibitory mechanisms of the cortex in vivo in humans. Several attempts have been made to track neuronal connectivity by applying direct electrical stimuli to the brain in order to stimulate subdural and/or depth electrodes and record responses from the functionally connected cortex. In vivo single-pulse electrical stimulation (SPES) and/or cortico-cortical evoked potential (CCEP) were recently introduced to track various brain networks. This article reviews the concepts, significance, methods, mechanisms, limitations, and clinical applications of CCEP in the analysis of these dynamic connections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.