ReviewNeurologia medico-chirurgica2015
Epilepsy surgery for pediatric epilepsy: optimal timing of surgical intervention.
Review in Neurologia medico-chirurgica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Preoperative predictors of seizure freedom after hemispheric surgery for rasmussen's encephalitis: An individual participant data meta-analysis.Neurosurgical review · 2026Pooled it
- Single-Neuron Recordings Research in Children: Ethical Considerations, Feasibility, Technical Aspects, and Scientific Opportunities.Pediatric neurosurgery · 2026Review
- Epilepsy surgery in COVID times-a unique conundrum.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Early Intervention via Stimulation of the Medial Septal Nucleus Improves Cognition and Alters Markers of Epileptogenesis in Pilocarpine-Induced Epilepsy.Frontiers in neurology · 2021Article
- Epilepsy surgery in children: what the radiologist needs to know.Neuroradiology · 2020Review
- The Biochemical Profile of Post-Mortem Brain from People Who Suffered from Epilepsy Reveals Novel Insights into the Etiopathogenesis of the Disease.Metabolites · 2020Article
- Recent Aspects of Pediatric Epilepsy Surgery.Journal of epilepsy research · 2019Review
- An update on pediatric surgical epilepsy: Part I.Surgical neurology international · 2019Review
- Neuroimaging of Early Life Epilepsy.Pediatrics · 2018Observational
- Resting state signal latency predicts laterality in pediatric medically refractory temporal lobe epilepsy.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- Significance of the expression of MRP1 and MRP2 in peripheral blood mononuclear cells of children with intractable epilepsy.Experimental and therapeutic medicine · 2015Article
- Mapping the cognitive landscape: a pilot study of domain-specific outcomes following frontal lobe resection in children with epilepsy.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pediatric epilepsy has a wide variety of etiology and severity. A recent epidemiological study suggested that surgery might be indicated in as many as 5% of the pediatric epilepsy population. Now, we know that effective epilepsy surgery can result in seizure freedom and improvement of psychomotor development. Seizure control is the most effective way to improve patients neurologically and psychologically. In this review, we look over the recent evidence related to pediatric epilepsy surgery, and try to establish the optimal surgical timing for patients with intractable epilepsy. Appropriate surgical timing depends on the etiology and natural history of the epilepsy to be treated. The most common etiology of pediatric intractable epilepsy patients is malformation of cortical development (MCD) and early surgery is recommended for them. Patients operated on earlier than 12 months of age tended to improve their psychomotor development compared to those operated on later. Recent progress in neuroimaging and electrophysiological studies provide the possibility of very early diagnosis and comprehensive surgical management even at an age before 12 months. Epilepsy surgery is the only solution for patients with MCD or other congenital diseases associated with intractable epilepsy, therefore physicians should aim at an early and precise diagnosis and predicting the future damage, consider a surgical solution within an optimal timing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.